952685-59-5

Upstream product

• 5337-03-1 tetrahydro-2H-pyran-4-carboxylic acid 
• 107-02-8 acrolein 
• 133243-97-7 3-(tetrahydro-4H-pyran-4-ylidene)propan-1-ol 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 428871-03-8 3-tetrahydropyran-4-yl-propan-1-ol 

Downstream Products

• 952685-60-8 (S)-dibenzyl 1-(1-hydroxy-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)hydrazine-1,2-dicarboxylate 
• 1307800-18-5 C₂₇H₃₅ClN₂O₃ 
• 1380805-46-8 (2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-1-[3-(tetrahydro-pyran-4-yl)-propyl]-pyrrolidine-3-carbonitrile 
• 1396135-14-0 chiral 4-((3S,3'R,5S,7S,7aR)-6'-chloro-7-(3-chloro-2-fluorophenyl)-5-neopentyl-1,2'-dioxo-3-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-1',2',7,7a-tetrahydrospiro[pyrrolo[1,2-c]imidazole-6,3'-pyrrolo[3,2-c]pyridine]-2(1H,3H,5H)-yl)-3-methoxybenzamide 

Relevant academic research and scientific papers

Acridine Photocatalysis: Insights into the Mechanism and Development of a Dual-Catalytic Direct Decarboxylative Conjugate Addition

Conjugate addition is one of the most synthetically useful carbon-carbon bond-forming reactions; however, reactive carbon nucleophiles are typically required to effect the addition. Radical conjugate addition provides an avenue for replacing reactive nucleophiles with convenient radical precursors. Carboxylic acids can serve as simple and stable radical precursors by way of decarboxylation, but activation to reactive esters is typically necessary to facilitate the challenging decarboxylation. Here, we report a direct, dual-catalytic decarboxylative radical conjugate addition of a wide range of carboxylic acids that does not require acid preactivation and is enabled by the visible light-driven acridine photocatalysis interfaced with an efficient copper catalytic cycle. Mechanistic and computational studies provide insights into the roles of the ligands and metal species in the dual-catalytic process and the photocatalytic activity of substituted acridines.

DIAMINOPROPANOL RENIN INHIBITORS

Described are diaminopropanols of which are orally active and bind to renin to inhibit its activity. They are useful in the treatment or amelioration of diseases associated with elevated levels of renin activity or in the treatment of aspartic protease me