3-(TETRAHYDRO-2H-PYRAN-4-YL)PROPANAL

Base Information

• Chemical Name: 3-(TETRAHYDRO-2H-PYRAN-4-YL)PROPANAL
• CAS No.: 952685-59-5
• Molecular Formula: C8H14O2
• Molecular Weight: 142.198
• Mol file: 952685-59-5.mol

Synonyms:3-(TETRAHYDRO-2H-PYRAN-4-YL)PROPANAL

Chemical Property of 3-(TETRAHYDRO-2H-PYRAN-4-YL)PROPANAL

Chemical Property:

• PSA: 26.30000
• LogP: 1.39210

Purity/Quality:

3-(Tetrahydro-2H-pyran-4-yl)propanal ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(TETRAHYDRO-2H-PYRAN-4-YL)PROPANAL

There total 4 articles about 3-(TETRAHYDRO-2H-PYRAN-4-YL)PROPANAL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-tetrahydropyran-4-yl-propan-1-ol (428871-03-8) → 3-(tetrahydro-2H-pyran-4-yl)propanal (952685-59-5)

Guidance literature:

3-tetrahydropyran-4-yl-propan-1-ol; With Dess-Martin periodane; In dichloromethane; at 20 ℃;

With potassium carbonate; In diethyl ether; dichloromethane;

Reference yield: 74.0%

tetrahydro-2H-pyran-4-carboxylic acid (5337-03-1) + acrolein (107-02-8,25068-14-8) → 3-(tetrahydro-2H-pyran-4-yl)propanal (952685-59-5)

Guidance literature:

With piperazine; 9-(2-chlorophenyl)acridine; tetrakis(acetonitrile)copper(I)tetrafluoroborate; In dichloromethane; at 25 - 27 ℃; for 14h; Irradiation;

DOI:10.1021/acscatal.0c03440

Reference yield:

Tetrahydro-4H-pyran-4-one (29943-42-8,143562-54-3) → 3-(tetrahydro-2H-pyran-4-yl)propanal (952685-59-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / 0 °C

1.2: 0 - 20 °C

2.1: hydrogen / palladium hydroxide on carbon / methanol

3.1: Dess-Martin periodane / dichloromethane / 20 °C

With n-butyllithium; hydrogen; Dess-Martin periodane; palladium hydroxide on carbon; In tetrahydrofuran; methanol; dichloromethane;

upstream raw materials:

3-tetrahydropyran-4-yl-propan-1-ol

Tetrahydro-4H-pyran-4-one

3-(tetrahydro-4H-pyran-4-ylidene)propan-1-ol

tetrahydro-2H-pyran-4-carboxylic acid

Downstream raw materials:

(S)-dibenzyl 1-(1-hydroxy-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)hydrazine-1,2-dicarboxylate

chiral 4-((3S,3'R,5S,7S,7aR)-6'-chloro-7-(3-chloro-2-fluorophenyl)-5-neopentyl-1,2'-dioxo-3-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-1',2',7,7a-tetrahydrospiro[pyrrolo[1,2-c]imidazole-6,3'-pyrrolo[3,2-c]pyridine]-2(1H,3H,5H)-yl)-3-methoxybenzamide

(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-1-[3-(tetrahydro-pyran-4-yl)-propyl]-pyrrolidine-3-carbonitrile

C₂₇H₃₅ClN₂O₃

Refernces

• 1、 -. "DIAMINOPROPANOL RENIN INHIBITORS". Page/Page column 104. . Retrieved 2008/06/13.