2,4,6-triisopropyl-benzenesulfonic acid 5-(4-methoxy-phenyl)-6-oxo-1,6-dihydro-pyridazin-3-yl ester

Base Information

• Chemical Name: 2,4,6-triisopropyl-benzenesulfonic acid 5-(4-methoxy-phenyl)-6-oxo-1,6-dihydro-pyridazin-3-yl ester
• CAS No.: 910229-68-4
• Molecular Formula: C₂₆H₃₂N₂O₅S
• Molecular Weight: 484.616
• Mol file: 910229-68-4.mol

Synonyms:2,4,6-triisopropyl-benzenesulfonic acid 5-(4-methoxy-phenyl)-6-oxo-1,6-dihydro-pyridazin-3-yl ester

Chemical Property of 2,4,6-triisopropyl-benzenesulfonic acid 5-(4-methoxy-phenyl)-6-oxo-1,6-dihydro-pyridazin-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4,6-triisopropyl-benzenesulfonic acid 5-(4-methoxy-phenyl)-6-oxo-1,6-dihydro-pyridazin-3-yl ester

There total 2 articles about 2,4,6-triisopropyl-benzenesulfonic acid 5-(4-methoxy-phenyl)-6-oxo-1,6-dihydro-pyridazin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-bromo-6-oxo-1,6-dihydropyridazin-3-yl 2,4,6-triisopropylbenzenesulfonate (910229-65-1) + 4-methoxyphenylboronic acid (5720-07-0) → 2,4,6-triisopropyl-benzenesulfonic acid 5-(4-methoxy-phenyl)-6-oxo-1,6-dihydro-pyridazin-3-yl ester (910229-68-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; at 150 ℃; for 0.25h;

DOI:10.1016/j.tetlet.2006.06.056

Reference yield:

2,4,6-triisopropylphenylsulfonyl chloride (6553-96-4) → 2,4,6-triisopropyl-benzenesulfonic acid 5-(4-methoxy-phenyl)-6-oxo-1,6-dihydro-pyridazin-3-yl ester (910229-68-4)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 2 h / 0 - 20 °C

2: 90 percent / Pd(PPh₃)4; sodium carbonate / 1,2-dimethoxy-ethane; H₂O / 0.25 h / 150 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; 2: Suzuki reaction;

DOI:10.1016/j.tetlet.2006.06.056

Reference yield: 68.0%

2,4,6-triisopropyl-benzenesulfonic acid 5-(4-methoxy-phenyl)-6-oxo-1,6-dihydro-pyridazin-3-yl ester (910229-68-4) + phenylboronic acid (98-80-6) → 4-(4-methoxyphenyl)-6-phenylpyridazin-3(2H)-one

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; at 155 ℃; for 0.666667h;

DOI:10.1016/j.tetlet.2006.06.056

upstream raw materials:

5-bromo-6-oxo-1,6-dihydropyridazin-3-yl 2,4,6-triisopropylbenzenesulfonate

4-methoxyphenylboronic acid

2,4,6-triisopropylphenylsulfonyl chloride