1,6-diphenyl-3-methyl-1H-pyrazolo[3,4-b]pyrazine-5-carboxamidoxime

Base Information

• Chemical Name: 1,6-diphenyl-3-methyl-1H-pyrazolo[3,4-b]pyrazine-5-carboxamidoxime
• CAS No.: 1593065-32-7
• Molecular Formula: C₁₉H₁₆N₆O
• Molecular Weight: 344.376
• Mol file: 1593065-32-7.mol

Synonyms:1,6-diphenyl-3-methyl-1H-pyrazolo[3,4-b]pyrazine-5-carboxamidoxime

Chemical Property of 1,6-diphenyl-3-methyl-1H-pyrazolo[3,4-b]pyrazine-5-carboxamidoxime

Chemical Property:

Purity/Quality:

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• Hazard Codes: 

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Technology Process of 1,6-diphenyl-3-methyl-1H-pyrazolo[3,4-b]pyrazine-5-carboxamidoxime

There total 1 articles about 1,6-diphenyl-3-methyl-1H-pyrazolo[3,4-b]pyrazine-5-carboxamidoxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

1,6-diphenyl-3-methyl-1H-pyrazolo[3,4-b]pyrazine-5-carbonitrile (214914-34-8) → 1,6-diphenyl-3-methyl-1H-pyrazolo[3,4-b]pyrazine-5-carboxamidoxime (1593065-32-7)

Guidance literature:

With hydroxylamine hydrochloride; potassium carbonate; In 1,4-dioxane; water; for 4h; Reflux; Heating;

DOI:10.1016/j.bmc.2014.02.019

Reference yield: 79.0%

1,6-diphenyl-3-methyl-1H-pyrazolo[3,4-b]pyrazine-5-carboxamidoxime (1593065-32-7) + 4-chloro-benzoyl chloride (122-01-0) → 5-(5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl)-1,6-diphenyl-3-methyl-1H-pyrazolo[3,4-b]pyrazine (1593065-34-9)

Guidance literature:

With pyridine; for 3h; Reflux; Heating;

DOI:10.1016/j.bmc.2014.02.019

Reference yield: 77.0%

1,6-diphenyl-3-methyl-1H-pyrazolo[3,4-b]pyrazine-5-carboxamidoxime (1593065-32-7) + benzoyl chloride (98-88-4) → 1,6-diphenyl-3-methyl-5-(5-phenyl-1,2,4-oxadiazol-3-yl)-1H-pyrazolo[3,4-b]pyrazine (1593065-33-8)

Guidance literature:

With pyridine; for 3h; Reflux; Heating;

DOI:10.1016/j.bmc.2014.02.019

upstream raw materials:

1,6-diphenyl-3-methyl-1H-pyrazolo[3,4-b]pyrazine-5-carbonitrile

Downstream raw materials:

1,6-diphenyl-3-methyl-5-(5-phenyl-1,2,4-oxadiazol-3-yl)-1H-pyrazolo[3,4-b]pyrazine

5-(5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl)-1,6-diphenyl-3-methyl-1H-pyrazolo[3,4-b]pyrazine