Technology Process of (2-(4-tributylstannylphenylamino)thiazol-4-yl)(3,4,5-trimethoxyphenyl)methanone
There total 5 articles about (2-(4-tributylstannylphenylamino)thiazol-4-yl)(3,4,5-trimethoxyphenyl)methanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-bromo-3,4,5-trimethoxybenzene;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.166667h;
Inert atmosphere;
N-methoxy-N-methyl-2-(4-tributylstannylphenylamino)thiazole-4-carboxamide;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 2.5h;
Inert atmosphere;
DOI:10.1002/jlcr.3178
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydroxide; ethanol / ethanol / 18 h / Reflux
2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 24 h / 20 °C
3.1: tetrakis(triphenylphosphine) palladium(0); lithium chloride; 2,6-di-tert-butyl-4-methyl-phenol / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere
4.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 °C / Inert atmosphere
4.2: 2.5 h / -78 - 20 °C / Inert atmosphere
With
4-methyl-morpholine; tetrakis(triphenylphosphine) palladium(0); n-butyllithium; ethanol; 2,6-di-tert-butyl-4-methyl-phenol; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium chloride; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane;
3.1: |Stille Cross-Coupling (Migita-Kosugi-Stille Coupling);
DOI:10.1002/jlcr.3178
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 24 h / 20 °C
2.1: tetrakis(triphenylphosphine) palladium(0); lithium chloride; 2,6-di-tert-butyl-4-methyl-phenol / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 °C / Inert atmosphere
3.2: 2.5 h / -78 - 20 °C / Inert atmosphere
With
4-methyl-morpholine; tetrakis(triphenylphosphine) palladium(0); n-butyllithium; 2,6-di-tert-butyl-4-methyl-phenol; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium chloride;
In
tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane;
2.1: |Stille Cross-Coupling (Migita-Kosugi-Stille Coupling);
DOI:10.1002/jlcr.3178
