N-(4-(2-oxo-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-1(2H)-yl)phenyl)pivalamide

Base Information

Chemical Name:N-(4-(2-oxo-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-1(2H)-yl)phenyl)pivalamide
CAS No.:1104452-34-7
Molecular Formula:C₂₈H₃₅N₅O₃
Molecular Weight:489.618
Hs Code.:

Synonyms:N-(4-(2-oxo-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-1(2H)-yl)phenyl)pivalamide

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Chemical Property of N-(4-(2-oxo-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-1(2H)-yl)phenyl)pivalamide

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Technology Process of N-(4-(2-oxo-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-1(2H)-yl)phenyl)pivalamide

There total 6 articles about N-(4-(2-oxo-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-1(2H)-yl)phenyl)pivalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1104451-27-5
1-(4-aminophenyl)-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one

: 3282-30-2
pivaloyl chloride

: 1104452-34-7
N-(4-(2-oxo-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-1(2H)-yl)phenyl)pivalamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm501175v

Reference yield:

: 219555-98-3
2-chloro-5-propylpyrimidine

: 1104452-34-7
N-(4-(2-oxo-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-1(2H)-yl)phenyl)pivalamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / dimethyl sulfoxide / 2 h / 100 °C / Inert atmosphere

2: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

3: potassium carbonate / dimethyl sulfoxide / 3 h / 100 °C / Inert atmosphere

4: copper(l) iodide; 8-quinolinol; potassium carbonate / dimethyl sulfoxide / 21 h / 100 - 140 °C / Inert atmosphere

5: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With copper(l) iodide; 8-quinolinol; potassium carbonate; triethylamine; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm501175v

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 1104452-34-7
N-(4-(2-oxo-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-1(2H)-yl)phenyl)pivalamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / dimethyl sulfoxide / 2 h / 100 °C / Inert atmosphere

2: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

3: potassium carbonate / dimethyl sulfoxide / 3 h / 100 °C / Inert atmosphere

4: copper(l) iodide; 8-quinolinol; potassium carbonate / dimethyl sulfoxide / 21 h / 100 - 140 °C / Inert atmosphere

5: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With copper(l) iodide; 8-quinolinol; potassium carbonate; triethylamine; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm501175v