Technology Process of 4-(2-(2-(N-(1,2,4-thiadiazol-5-yl)sulfamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)-5-(trifluoromethyl)phenyl)-1,1-dimethyl-1,2,3,6-tetrahydropyridin-1-ium hydroxide
There total 8 articles about 4-(2-(2-(N-(1,2,4-thiadiazol-5-yl)sulfamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)-5-(trifluoromethyl)phenyl)-1,1-dimethyl-1,2,3,6-tetrahydropyridin-1-ium hydroxide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-(2-(1,2,3,6-tetrahydropyridin-4-yl)-4-(trifluoromethyl)phenyl)-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide hydrochloride; methyl iodide;
With
N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran;
at 20 ℃;
With
ammonium hydroxide;
In
methanol; water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine; sulfuryl dichloride / dichloromethane / -78 °C
1.2: 4 h
2.1: potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; 1,4-dioxane / 2 h / 120 °C
3.1: hydrogenchloride / 1,4-dioxane / 1 h / 80 °C
4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C
With
hydrogenchloride; potassium phosphate; sulfuryl dichloride; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); triethylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / water; 1,4-dioxane / 100 °C
1.2: 3 h / 130 °C / Microwave irradiation
2.1: methanol; acetyl chloride / tetrahydrofuran / 0 °C
3.1: triethylamine; sulfuryl dichloride / dichloromethane / -78 °C
3.2: 4 h
4.1: potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; 1,4-dioxane / 2 h / 120 °C
5.1: hydrogenchloride / 1,4-dioxane / 1 h / 80 °C
6.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C
With
hydrogenchloride; methanol; potassium phosphate; sulfuryl dichloride; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; acetyl chloride;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
