5-(2-bromo-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

Base Information

Chemical Name:5-(2-bromo-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride
CAS No.:1454667-12-9
Molecular Formula:C₁₆H₁₃BrF₃N*ClH
Molecular Weight:392.646
Hs Code.:

Synonyms:5-(2-bromo-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

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Chemical Property of 5-(2-bromo-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

Chemical Property:

Purity/Quality:

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Technology Process of 5-(2-bromo-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

There total 4 articles about 5-(2-bromo-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1454667-10-7
tert-butyl 5-(2-bromo-4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1454667-12-9
5-(2-bromo-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

Guidance literature:: With methanol; acetyl chloride; In tetrahydrofuran; at 0 ℃;

Reference yield:

: 215184-78-4
5-bromo-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

: 1454667-12-9
5-(2-bromo-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 48 h / 120 °C / Inert atmosphere

2.1: potassium carbonate / water; 1,4-dioxane / 100 °C

2.2: 3 h / 130 °C / Microwave irradiation

3.1: methanol; acetyl chloride / tetrahydrofuran / 0 °C

With methanol; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; acetyl chloride; XPhos; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 1035235-26-7
tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1454667-12-9
5-(2-bromo-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / water; 1,4-dioxane / 100 °C

1.2: 3 h / 130 °C / Microwave irradiation

2.1: methanol; acetyl chloride / tetrahydrofuran / 0 °C

With methanol; potassium carbonate; acetyl chloride; In tetrahydrofuran; 1,4-dioxane; water;