2-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-[1,3]dioxane-5,5-dicarboxylic acid bis-[(1-hydroxymethyl-2,2-dimethyl-propyl)-amide]

Base Information

• Chemical Name: 2-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-[1,3]dioxane-5,5-dicarboxylic acid bis-[(1-hydroxymethyl-2,2-dimethyl-propyl)-amide]
• CAS No.: 853065-13-1
• Molecular Formula: C₃₁H₅₄N₂O₇Si
• Molecular Weight: 594.864

Synonyms:2-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-[1,3]dioxane-5,5-dicarboxylic acid bis-[(1-hydroxymethyl-2,2-dimethyl-propyl)-amide]

Chemical Property of 2-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-[1,3]dioxane-5,5-dicarboxylic acid bis-[(1-hydroxymethyl-2,2-dimethyl-propyl)-amide]

Chemical Property:

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Technology Process of 2-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-[1,3]dioxane-5,5-dicarboxylic acid bis-[(1-hydroxymethyl-2,2-dimethyl-propyl)-amide]

There total 3 articles about 2-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-[1,3]dioxane-5,5-dicarboxylic acid bis-[(1-hydroxymethyl-2,2-dimethyl-propyl)-amide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

Lithium; (S)-2-amino-3,3-dimethyl-butan-1-olate + 2-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-[1,3]dioxane-5,5-dicarboxylic acid diethyl ester (853065-09-5) → 2-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-[1,3]dioxane-5,5-dicarboxylic acid bis-[(1-hydroxymethyl-2,2-dimethyl-propyl)-amide] (853065-13-1)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1016/j.tetasy.2005.02.026

Reference yield:

diethyl bis(hydroxymethyl)malonate (20605-01-0) → 2-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-[1,3]dioxane-5,5-dicarboxylic acid bis-[(1-hydroxymethyl-2,2-dimethyl-propyl)-amide] (853065-13-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / p-TsOH / toluene / Heating

2: 45 percent / tetrahydrofuran / 16 h / 20 °C

With toluene-4-sulfonic acid; In tetrahydrofuran; toluene;

DOI:10.1016/j.tetasy.2005.02.026

Reference yield:

4-((tert-butyldimethylsilyloxy)methyl)benzaldehyde (160744-60-5) → 2-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-[1,3]dioxane-5,5-dicarboxylic acid bis-[(1-hydroxymethyl-2,2-dimethyl-propyl)-amide] (853065-13-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / p-TsOH / toluene / Heating

2: 45 percent / tetrahydrofuran / 16 h / 20 °C

With toluene-4-sulfonic acid; In tetrahydrofuran; toluene;

DOI:10.1016/j.tetasy.2005.02.026

upstream raw materials:

2-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-[1,3]dioxane-5,5-dicarboxylic acid diethyl ester

diethyl bis(hydroxymethyl)malonate

4-((tert-butyldimethylsilyloxy)methyl)benzaldehyde

Downstream raw materials:

C₃₁H₅₀N₂O₅Si

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