4-(3-Fluorophenyl)but-3-enoic acid

Base Information

Chemical Name:4-(3-Fluorophenyl)but-3-enoic acid
CAS No.:127404-67-5
Molecular Formula:C₁₀H₉FO₂
Molecular Weight:180.179
Hs Code.:
DSSTox Substance ID:DTXSID301279972

Synonyms:4-(3-fluorophenyl)but-3-enoic acid;127404-67-5;(E)-4-(3-fluorophenyl)but-3-enoic acid;934637-08-8;4-(3-Fluorophenyl)-3-butenoic Acid;4-(3-Fluorophenyl)-3-butenoicAcid;MFCD18324917;SCHEMBL3292454;DTXSID301279972;CFA40467;AC7961;AKOS023430207;AS-30382;(3E)-4-(3-Fluorophenyl)-3-butenoic acid;CS-0307915;EN300-100831;EN300-7402774;A916213;(3E)-4-(3-FLUOROPHENYL)BUT-3-ENOIC ACID;Z1350606434

Suppliers and Price of 4-(3-Fluorophenyl)but-3-enoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 4-(3-Fluorophenyl)but-3-enoic acid

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:180.05865769
Heavy Atom Count:13
Complexity:201

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC(=C1)F)C=CCC(=O)O
Isomeric SMILES:C1=CC(=CC(=C1)F)/C=C/CC(=O)O

Technology Process of 4-(3-Fluorophenyl)but-3-enoic acid

There total 5 articles about 4-(3-Fluorophenyl)but-3-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 64-18-6
formic acid

: 38340-15-7
(+/-)-1-(3'-fluorophenyl)prop-2-en-1-ol

: 127404-67-5,934637-08-8
(E)-4-(3-fluorophenyl)but-3-enoic acid

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; acetic anhydride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 80 ℃; for 12h; regioselective reaction; Schlenk technique; Inert atmosphere;
DOI:10.1002/chem.201701971

Reference yield: 58.0%

: 51114-94-4
(2-carboxyethyl)triphenylphosphonium bromide

: 456-48-4
3-Fluorobenzaldehyde

: 127404-67-5,934637-08-8
4-(3-fluoro-phenyl)-but-3-enoic acid

Guidance literature:: (2-carboxyethyl)triphenylphosphonium bromide; 3-Fluorobenzaldehyde; With potassium tert-butylate; In tetrahydrofuran; at -78 - 20 ℃;

With hydrogenchloride; In water; pH=1;

Reference yield:

: 51114-94-4
(2-carboxyethyl)triphenylphosphonium bromide

: 456-48-4
3-Fluorobenzaldehyde

: 934637-08-8
4-(3-fluoro-phenyl)-but-3-enoic acid

: 127404-67-5,934637-08-8
(E)-4-(3-fluorophenyl)but-3-enoic acid

: 791-28-6
Triphenylphosphine oxide

Guidance literature:: (2-carboxyethyl)triphenylphosphonium bromide; 3-Fluorobenzaldehyde; With potassium tert-butylate; In dichloromethane; at 0 - 20 ℃;

With hydrogenchloride; In water; pH=1;