1-(3-carbamoyl-5-chlorobenzyl)-5-chloro-2-imino-1,2-dihydropyridine-3-carboxamide monohydrobromide

Base Information

Chemical Name:1-(3-carbamoyl-5-chlorobenzyl)-5-chloro-2-imino-1,2-dihydropyridine-3-carboxamide monohydrobromide
CAS No.:1021873-47-1
Molecular Formula:BrH*C₁₄H₁₂Cl₂N₄O₂
Molecular Weight:420.093
Hs Code.:

Synonyms:1-(3-carbamoyl-5-chlorobenzyl)-5-chloro-2-imino-1,2-dihydropyridine-3-carboxamide monohydrobromide

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Chemical Property of 1-(3-carbamoyl-5-chlorobenzyl)-5-chloro-2-imino-1,2-dihydropyridine-3-carboxamide monohydrobromide

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Technology Process of 1-(3-carbamoyl-5-chlorobenzyl)-5-chloro-2-imino-1,2-dihydropyridine-3-carboxamide monohydrobromide

There total 7 articles about 1-(3-carbamoyl-5-chlorobenzyl)-5-chloro-2-imino-1,2-dihydropyridine-3-carboxamide monohydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 58483-97-9
2-amino-5-chloropyridine-3-carboxamide

: 1021871-33-9
3-(bromomethyl)-5-chlorobenzamide

: 1021873-47-1
1-(3-carbamoyl-5-chlorobenzyl)-5-chloro-2-imino-1,2-dihydropyridine-3-carboxamide monohydrobromide

Guidance literature:: In N,N-dimethyl-formamide; at 100 ℃; for 3h;
DOI:10.1021/acs.jmedchem.5b01528

Reference yield:

: 917388-36-4
methyl 3-carbamoyl-5-chlorobenzoate

: 1021873-47-1
1-(3-carbamoyl-5-chlorobenzyl)-5-chloro-2-imino-1,2-dihydropyridine-3-carboxamide monohydrobromide

Guidance literature:: Multi-step reaction with 3 steps

1: lithium borohydride / ethanol; tetrahydrofuran / 2 h / 60 °C

2: triphenylphosphine; bromine / acetonitrile / 2 h / 85 °C

3: N,N-dimethyl-formamide / 3 h / 100 °C

With lithium borohydride; bromine; triphenylphosphine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.jmedchem.5b01528

Reference yield:

: C₉H₆Cl₂O₃

: 1021873-47-1
1-(3-carbamoyl-5-chlorobenzyl)-5-chloro-2-imino-1,2-dihydropyridine-3-carboxamide monohydrobromide

Guidance literature:: Multi-step reaction with 4 steps

1: ammonia / methanol; tetrahydrofuran / 14 h / 0 - 20 °C

2: lithium borohydride / ethanol; tetrahydrofuran / 2 h / 60 °C

3: triphenylphosphine; bromine / acetonitrile / 2 h / 85 °C

4: N,N-dimethyl-formamide / 3 h / 100 °C

With lithium borohydride; ammonia; bromine; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.jmedchem.5b01528