methyl 2-(4-methoxyphenyl)-6-(trifluoromethyl)quinoline-4-carboxylate

Base Information

• Chemical Name: methyl 2-(4-methoxyphenyl)-6-(trifluoromethyl)quinoline-4-carboxylate
• CAS No.: 1314006-02-4
• Molecular Formula: C₁₉H₁₄F₃NO₃
• Molecular Weight: 361.32
• Mol file: 1314006-02-4.mol

Synonyms:methyl 2-(4-methoxyphenyl)-6-(trifluoromethyl)quinoline-4-carboxylate

Chemical Property of methyl 2-(4-methoxyphenyl)-6-(trifluoromethyl)quinoline-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of methyl 2-(4-methoxyphenyl)-6-(trifluoromethyl)quinoline-4-carboxylate

There total 2 articles about methyl 2-(4-methoxyphenyl)-6-(trifluoromethyl)quinoline-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C18H12F3NO3 (897571-13-0) + methyl iodide (74-88-4) → methyl 2-(4-methoxyphenyl)-6-(trifluoromethyl)quinoline-4-carboxylate (1314006-02-4)

Guidance literature:

With potassium carbonate; In acetone; for 5h; Reflux;

DOI:10.1016/j.bmc.2011.04.039

Reference yield:

5-(trifluoromethyl)isatin (345-32-4) + 1-(4-methoxyphenyl)ethanone (100-06-1) → methyl 2-(4-methoxyphenyl)-6-(trifluoromethyl)quinoline-4-carboxylate (1314006-02-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide / 0.5 h / Reflux

1.2: 20 h / Reflux

2.1: potassium carbonate / acetone / 5 h / Reflux

With potassium carbonate; potassium hydroxide; In acetone; 1.1: Pfitzinger reaction / 1.2: Pfitzinger reaction;

DOI:10.1016/j.bmc.2011.04.039

upstream raw materials:

C₁₈H₁₂F₃NO₃

methyl iodide

5-(trifluoromethyl)isatin

1-(4-methoxyphenyl)ethanone