3-Methyl-5-oxo-4-(1,1,3-trioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-2,5-dihydro-pyrazole-1-carboxylic acid phenylamide

Base Information

• Chemical Name: 3-Methyl-5-oxo-4-(1,1,3-trioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-2,5-dihydro-pyrazole-1-carboxylic acid phenylamide
• CAS No.: 177544-15-9
• Molecular Formula: C₁₈H₁₄N₄O₅S
• Molecular Weight: 398.399
• Mol file: 177544-15-9.mol

Synonyms:3-Methyl-5-oxo-4-(1,1,3-trioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-2,5-dihydro-pyrazole-1-carboxylic acid phenylamide

Chemical Property of 3-Methyl-5-oxo-4-(1,1,3-trioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-2,5-dihydro-pyrazole-1-carboxylic acid phenylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Methyl-5-oxo-4-(1,1,3-trioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-2,5-dihydro-pyrazole-1-carboxylic acid phenylamide

There total 5 articles about 3-Methyl-5-oxo-4-(1,1,3-trioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-2,5-dihydro-pyrazole-1-carboxylic acid phenylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

C19H18N4O6S → 3-Methyl-5-oxo-4-(1,1,3-trioxo-1,3-dihydro-1λ6-benzo[d]isothiazol-2-yl)-2,5-dihydro-pyrazole-1-carboxylic acid phenylamide (177544-15-9)

Guidance literature:

With sodium hydride; In methanol; for 0.5h; Ambient temperature;

DOI:10.1055/s-1996-4231

Reference yield: 71.0%

C20H20N4O6S → 3-Methyl-5-oxo-4-(1,1,3-trioxo-1,3-dihydro-1λ6-benzo[d]isothiazol-2-yl)-2,5-dihydro-pyrazole-1-carboxylic acid phenylamide (177544-15-9)

Guidance literature:

With sodium hydride; In methanol; for 0.1h; Ambient temperature;

DOI:10.1055/s-1996-4231

Reference yield:

saccharin (81-07-2) → 3-Methyl-5-oxo-4-(1,1,3-trioxo-1,3-dihydro-1λ6-benzo[d]isothiazol-2-yl)-2,5-dihydro-pyrazole-1-carboxylic acid phenylamide (177544-15-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / NaOMe / tetrahydrofuran / 24 h / Ambient temperature

2: 71 percent / NaH / methanol / 0.5 h / Ambient temperature

With sodium methylate; sodium hydride; In tetrahydrofuran; methanol;

DOI:10.1055/s-1996-4231

upstream raw materials:

3-phenylcarbamoylazo-crotonic acid ethyl ester

methyl (E)-3-[(phenylcarbamoyl)diazenyl]but-2-enoate

saccharin