N-(4-Propionylamino-phenyl)-3-(4-pyridin-2-yl-piperazin-1-yl)-propionamide

Base Information

Chemical Name:N-(4-Propionylamino-phenyl)-3-(4-pyridin-2-yl-piperazin-1-yl)-propionamide
CAS No.:86523-80-0
Molecular Formula:C₂₁H₂₇N₅O₂
Molecular Weight:381.478
Hs Code.:

Synonyms:N-(4-Propionylamino-phenyl)-3-(4-pyridin-2-yl-piperazin-1-yl)-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-Propionylamino-phenyl)-3-(4-pyridin-2-yl-piperazin-1-yl)-propionamide

Chemical Property:

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Technology Process of N-(4-Propionylamino-phenyl)-3-(4-pyridin-2-yl-piperazin-1-yl)-propionamide

There total 3 articles about N-(4-Propionylamino-phenyl)-3-(4-pyridin-2-yl-piperazin-1-yl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 123-62-6
propionic acid anhydride

: 86523-76-4
N-(4-aminophenyl)-3-<4-(2-pyridinyl)-1-piperazinyl>propanamide

: 86523-80-0
N-(4-Propionylamino-phenyl)-3-(4-pyridin-2-yl-piperazin-1-yl)-propionamide

Guidance literature:: In chloroform; for 6h; Heating;
DOI:10.1021/jm00384a002

Reference yield:

: 34803-66-2
1-(2-pyridyl)piperazine

: 86523-80-0
N-(4-Propionylamino-phenyl)-3-(4-pyridin-2-yl-piperazin-1-yl)-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 69 percent / benzene / Heating

2: 73 percent / H₂ / 10percent Pd/C / methanol / 3102.9 Torr

3: 76 percent / CHCl₃ / 6 h / Heating

With hydrogen; palladium on activated charcoal; In methanol; chloroform; benzene;
DOI:10.1021/jm00384a002

Reference yield:

: 86523-75-3
N-(4-Nitro-phenyl)-3-(4-pyridin-2-yl-piperazin-1-yl)-propionamide

: 86523-80-0
N-(4-Propionylamino-phenyl)-3-(4-pyridin-2-yl-piperazin-1-yl)-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / H₂ / 10percent Pd/C / methanol / 3102.9 Torr

2: 76 percent / CHCl₃ / 6 h / Heating

With hydrogen; palladium on activated charcoal; In methanol; chloroform;
DOI:10.1021/jm00384a002