N-(2-chlorophenyl)-n-hexylamine

Base Information

• Chemical Name: N-(2-chlorophenyl)-n-hexylamine
• CAS No.: 626201-29-4
• Molecular Formula: C₁₂H₁₈ClN
• Molecular Weight: 211.735
• Mol file: 626201-29-4.mol

Synonyms:N-(2-chlorophenyl)-n-hexylamine

Chemical Property of N-(2-chlorophenyl)-n-hexylamine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-(2-chlorophenyl)-n-hexylamine

There total 4 articles about N-(2-chlorophenyl)-n-hexylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1-bromo-hexane (111-25-1) + o-chloroaniline (95-51-2) → N-(2-chlorophenyl)-n-hexylamine (626201-29-4)

Guidance literature:

With lipase from Pseudomonas sp. strain; In ethanol; at 45 ℃; for 6h; chemoselective reaction;

DOI:10.1007/s10562-010-0479-9

Reference yield: 75.0%

hexan-1-amine (111-26-2) + 2-chlorophenyl nonaflate (147641-13-2) → N-(2-chlorophenyl)-n-hexylamine (626201-29-4)

Guidance literature:

With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In toluene; at 105 ℃; for 24h;

DOI:10.1021/jo034962a

Reference yield:

2-monochlorophenol (95-57-8) → N-(2-chlorophenyl)-n-hexylamine (626201-29-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / i-Pr₂NEt; DMAP / CH₂Cl₂ / 12 h / 20 °C

2: 75 percent / t-BuONa; 2,2'-(PPh₂)2-1,1'-binaphthyl / Pd₂dba3 / toluene / 24 h / 105 °C

With dmap; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In dichloromethane; toluene;

DOI:10.1021/jo034962a

upstream raw materials:

hexan-1-amine

2-chlorophenyl nonaflate

2-monochlorophenol

1-bromo-hexane

Downstream raw materials:

C₁₃H₁₇Cl₂NO