ethyl 9-(allyloxy)-3-(3-fluorophenyl)-8-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylate

Base Information

Chemical Name:ethyl 9-(allyloxy)-3-(3-fluorophenyl)-8-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylate
CAS No.:1428796-68-2
Molecular Formula:C₂₅H₂₄FNO₄
Molecular Weight:421.468
Hs Code.:

Synonyms:ethyl 9-(allyloxy)-3-(3-fluorophenyl)-8-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylate

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Chemical Property of ethyl 9-(allyloxy)-3-(3-fluorophenyl)-8-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylate

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Technology Process of ethyl 9-(allyloxy)-3-(3-fluorophenyl)-8-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylate

There total 7 articles about ethyl 9-(allyloxy)-3-(3-fluorophenyl)-8-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428796-66-0
ethyl 3-(3-fluorophenyl)-9-hydroxy-8-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylate

: 107-05-1
3-chloroprop-1-ene

: 1428796-68-2
ethyl 9-(allyloxy)-3-(3-fluorophenyl)-8-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 18h;

Reference yield:

: 1428797-11-8
ethyl 3-(3-fluorophenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylate

: 1428796-68-2
ethyl 9-(allyloxy)-3-(3-fluorophenyl)-8-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: aluminum (III) chloride / 1,2-dichloro-ethane / 1.25 h / 50 °C

2: potassium carbonate / N,N-dimethyl-formamide / 18 h / 60 °C

With aluminum (III) chloride; potassium carbonate; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 70-23-5
ethyl Bromopyruvate

: 1428796-68-2
ethyl 9-(allyloxy)-3-(3-fluorophenyl)-8-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 2 h / Inert atmosphere; Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 65 °C

3: palladium diacetate; caesium carbonate; triphenylphosphine / 1,4-dioxane / 22 h / 110 °C / Inert atmosphere; Sealed tube

4: boron tribromide / dichloromethane / 2.5 h / -40 °C / Inert atmosphere

5: potassium carbonate / N,N-dimethyl-formamide / 18 h / 60 °C

With palladium diacetate; boron tribromide; potassium carbonate; caesium carbonate; triphenylphosphine; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;