1-(7-amino-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-(3-chloro-4-fluoro-phenyl)-1-[3-(4-methyl-piperazin-1-yl)-propyl]-urea

Base Information

Chemical Name:1-(7-amino-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-(3-chloro-4-fluoro-phenyl)-1-[3-(4-methyl-piperazin-1-yl)-propyl]-urea
CAS No.:884875-57-4
Molecular Formula:C₂₅H₃₃ClFN₅O
Molecular Weight:474.021
Hs Code.:

Synonyms:1-(7-amino-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-(3-chloro-4-fluoro-phenyl)-1-[3-(4-methyl-piperazin-1-yl)-propyl]-urea

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Chemical Property of 1-(7-amino-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-(3-chloro-4-fluoro-phenyl)-1-[3-(4-methyl-piperazin-1-yl)-propyl]-urea

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Technology Process of 1-(7-amino-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-(3-chloro-4-fluoro-phenyl)-1-[3-(4-methyl-piperazin-1-yl)-propyl]-urea

There total 4 articles about 1-(7-amino-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-(3-chloro-4-fluoro-phenyl)-1-[3-(4-methyl-piperazin-1-yl)-propyl]-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 884875-42-7
3-(3-chloro-4-fluoro-phenyl)-1-[3-(4-methyl-piperazin-1-yl)-propyl]-1-(7-nitro-1,2,3,4-tetrahydro-naphthalen-2-yl)-urea

: 884875-57-4
1-(7-amino-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-(3-chloro-4-fluoro-phenyl)-1-[3-(4-methyl-piperazin-1-yl)-propyl]-urea

Guidance literature:: With hydrogen; nickel; In ethanol; at 20 ℃; for 2h; under 2585.74 Torr;
DOI:10.1016/j.bmcl.2006.12.080

Reference yield:

: 4572-03-6
3-(N-methylpiperazino)propylamine

: 884875-57-4
1-(7-amino-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-(3-chloro-4-fluoro-phenyl)-1-[3-(4-methyl-piperazin-1-yl)-propyl]-urea

Guidance literature:: Multi-step reaction with 4 steps

1: Ti(O-i-Pr)4 / 3 h / 80 °C

2: NaBH₄ / methanol / 12 h / 0 - 20 °C

3: 48 percent / i-Pr₂NEt / CH₂Cl₂

4: 75 percent / H₂ / Raney Ni / ethanol / 2 h / 20 °C / 2585.74 Torr

With titanium(IV) isopropylate; sodium tetrahydroborate; hydrogen; N-ethyl-N,N-diisopropylamine; nickel; In methanol; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2006.12.080

Reference yield:

: 934464-03-6
[3-(4-methyl-piperazin-1-yl)-propyl]-(7-nitro-1,2,3,4-tetrahydro-naphthalen-2-yl)-amine

: 884875-57-4
1-(7-amino-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-(3-chloro-4-fluoro-phenyl)-1-[3-(4-methyl-piperazin-1-yl)-propyl]-urea

Guidance literature:: Multi-step reaction with 2 steps

1: 48 percent / i-Pr₂NEt / CH₂Cl₂

2: 75 percent / H₂ / Raney Ni / ethanol / 2 h / 20 °C / 2585.74 Torr

With hydrogen; N-ethyl-N,N-diisopropylamine; nickel; In ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2006.12.080