Technology Process of C20H19FN4O3
There total 10 articles about C20H19FN4O3 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium azide;
In
dimethyl sulfoxide;
at 65 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: ethanol; sodium / toluene / 2 h / 80 - 85 °C
1.2: 2 h / 80 °C
2.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 2844.39 Torr
3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 12 h / 20 °C
4.1: phosphorus pentachloride / dichloromethane / 2.5 h / 20 °C
5.1: sulfur / 0.33 h / 165 °C
6.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
7.1: methanesulfonyl chloride; triethylamine / dichloromethane / 2 h / 0 °C
7.2: 20 °C
8.1: sodium azide / dimethyl sulfoxide / 2 h / 65 °C
With
hydrogenchloride; lithium aluminium tetrahydride; sodium azide; ethanol; phosphorus pentachloride; hydrogen; sodium; benzotriazol-1-ol; sulfur; methanesulfonyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 2844.39 Torr
2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 12 h / 20 °C
3.1: phosphorus pentachloride / dichloromethane / 2.5 h / 20 °C
4.1: sulfur / 0.33 h / 165 °C
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
6.1: methanesulfonyl chloride; triethylamine / dichloromethane / 2 h / 0 °C
6.2: 20 °C
7.1: sodium azide / dimethyl sulfoxide / 2 h / 65 °C
With
hydrogenchloride; lithium aluminium tetrahydride; sodium azide; phosphorus pentachloride; hydrogen; benzotriazol-1-ol; sulfur; methanesulfonyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide;