2,4,5-trichloro-6-(5-(4-fluorophenylamino)-4-oxo-3,4-dihydroquinazolin-8-ylamino)isophthalonitrile

Base Information

Chemical Name:2,4,5-trichloro-6-(5-(4-fluorophenylamino)-4-oxo-3,4-dihydroquinazolin-8-ylamino)isophthalonitrile
CAS No.:1469772-05-1
Molecular Formula:C₂₂H₁₀Cl₃FN₆O
Molecular Weight:499.718
Hs Code.:

Synonyms:2,4,5-trichloro-6-(5-(4-fluorophenylamino)-4-oxo-3,4-dihydroquinazolin-8-ylamino)isophthalonitrile

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Chemical Property of 2,4,5-trichloro-6-(5-(4-fluorophenylamino)-4-oxo-3,4-dihydroquinazolin-8-ylamino)isophthalonitrile

Chemical Property:

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Technology Process of 2,4,5-trichloro-6-(5-(4-fluorophenylamino)-4-oxo-3,4-dihydroquinazolin-8-ylamino)isophthalonitrile

There total 4 articles about 2,4,5-trichloro-6-(5-(4-fluorophenylamino)-4-oxo-3,4-dihydroquinazolin-8-ylamino)isophthalonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1897-45-6
chlorothalonil

: 1469771-93-4
8-amino-5-(4-fluorophenylamino)quinazolin-4(3H)-one

: 1469772-05-1
2,4,5-trichloro-6-(5-(4-fluorophenylamino)-4-oxo-3,4-dihydroquinazolin-8-ylamino)isophthalonitrile

Guidance literature:: With potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; at 75 ℃; for 1h;
DOI:10.1016/j.bmcl.2013.08.068

Reference yield:

: 400784-50-1
5-chloro-8-nitro-quinazolin-4(3H)-one

: 1469772-05-1
2,4,5-trichloro-6-(5-(4-fluorophenylamino)-4-oxo-3,4-dihydroquinazolin-8-ylamino)isophthalonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran; N,N-dimethyl-formamide / 12 h / 80 °C

2: hydrogen; palladium 10% on activated carbon / tetrahydrofuran

3: potassium carbonate / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 75 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.08.068

Reference yield:

: 1469771-80-9
C₁₄H₉FN₄O₃

: 1469772-05-1
2,4,5-trichloro-6-(5-(4-fluorophenylamino)-4-oxo-3,4-dihydroquinazolin-8-ylamino)isophthalonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran

2: potassium carbonate / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 75 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.08.068