{[5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yl]-methyl-amino}-acetic acid ethyl ester

Base Information

Chemical Name:{[5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yl]-methyl-amino}-acetic acid ethyl ester
CAS No.:1299489-75-0
Molecular Formula:C₂₆H₂₄F₂N₂O₅
Molecular Weight:482.484
Hs Code.:

Synonyms:{[5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yl]-methyl-amino}-acetic acid ethyl ester

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Chemical Property of {[5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yl]-methyl-amino}-acetic acid ethyl ester

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Technology Process of {[5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yl]-methyl-amino}-acetic acid ethyl ester

There total 10 articles about {[5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yl]-methyl-amino}-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1299489-67-0
[5-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d] isoxazol-3-yl]-methyl-amine

: 105-36-2
ethyl bromoacetate

: 1299489-75-0
{[5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yl]-methyl-amino}-acetic acid ethyl ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 79.92h;

Reference yield:

: 64113-84-4
2-fluoro-5-methylbenzonitrile

: 1299489-75-0
{[5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yl]-methyl-amino}-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium tert-butylate / tetrahydrofuran / 20 °C / Reflux

1.2: 2 h / Reflux

1.3: pH 12

2.1: dmap / dichloromethane / 20 °C

3.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 3 h / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide; tetrahydrofuran

5.1: hydrazine hydrate / ethanol / 3.5 h

6.1: potassium carbonate / 6 h

6.2: 1 h

7.1: caesium carbonate / N,N-dimethyl-formamide / 79.92 h / 120 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; potassium carbonate; caesium carbonate; hydrazine hydrate; dmap; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 540-38-5
p-Iodophenol

: 1299489-75-0
{[5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yl]-methyl-amino}-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 1 h / 80 - 85 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide; tetrahydrofuran

3.1: hydrazine hydrate / ethanol / 3.5 h

4.1: potassium carbonate / 6 h

4.2: 1 h

5.1: caesium carbonate / N,N-dimethyl-formamide / 79.92 h / 120 °C

With potassium carbonate; caesium carbonate; hydrazine hydrate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;