methyl 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-(R)-phenyl-1-piperidineacetate

Base Information

Chemical Name:methyl 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-(R)-phenyl-1-piperidineacetate
CAS No.:676517-68-3
Molecular Formula:C₂₆H₃₂Cl₂N₂O₃
Molecular Weight:491.458
Hs Code.:

Synonyms:methyl 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-(R)-phenyl-1-piperidineacetate

Suppliers and Price of methyl 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-(R)-phenyl-1-piperidineacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-(R)-phenyl-1-piperidineacetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-(R)-phenyl-1-piperidineacetate

There total 8 articles about methyl 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-(R)-phenyl-1-piperidineacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 676517-50-3
4-[4-(3,4-dichloro-phenoxy)-piperidin-1-ylmethyl]-cyclopentane-1,2-diol

: 19883-41-1,13226-98-7
D-phenylglycine methyl ester hydrochloride

: 676517-68-3
methyl 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-(R)-phenyl-1-piperidineacetate

Guidance literature:: 4-[4-(3,4-dichloro-phenoxy)-piperidin-1-ylmethyl]-cyclopentane-1,2-diol; With lead(IV) tetraacetate; sodium carbonate; In dichloromethane; at 0 ℃; for 0.666667h;

D-phenylglycine methyl ester hydrochloride; With sodium tris(acetoxy)borohydride; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 245057-73-2
4-(3,4-dichloro-phenoxy)-piperidine

: 676517-68-3
methyl 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-(R)-phenyl-1-piperidineacetate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 2 h / 0 °C

2: potassium osmate(VI) dihydrate; 4-methylmorpholine N-oxide / acetone; water / 18 h / 20 °C

3: borane-THF / tetrahydrofuran / 2 h / Reflux

4: acetic acid; sodium periodate / water / 1 h / 20 °C

5: sodium triacetoxy borohydride; acetic acid / 18 h / 20 °C

With potassium osmate(VI) dihydrate; sodium periodate; borane-THF; sodium triacetoxy borohydride; acetic acid; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; dichloromethane; water; acetone;
DOI:10.1016/j.bmcl.2012.08.103

Reference yield:

: 676517-52-5
1-(3-cyclopenten-1-ylcarbonyl)-4-(3,4-dichlorophenoxy)piperidine

: 676517-68-3
methyl 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-(R)-phenyl-1-piperidineacetate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium osmate(VI) dihydrate; 4-methylmorpholine N-oxide / acetone; water / 18 h / 20 °C

2: borane-THF / tetrahydrofuran / 2 h / Reflux

3: acetic acid; sodium periodate / water / 1 h / 20 °C

4: sodium triacetoxy borohydride; acetic acid / 18 h / 20 °C

With potassium osmate(VI) dihydrate; sodium periodate; borane-THF; sodium triacetoxy borohydride; acetic acid; 4-methylmorpholine N-oxide; In tetrahydrofuran; water; acetone;
DOI:10.1016/j.bmcl.2012.08.103