Technology Process of methyl (R)-3-(benzyloxy)icosanoate
There total 3 articles about methyl (R)-3-(benzyloxy)icosanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylsilane; Hexamethyldisiloxane; trimethylsilyl trifluoromethanesulfonate;
In
tetrahydrofuran;
at 0 - 20 ℃;
DOI:10.1016/j.tet.2004.10.017
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 77 percent / hydrogen; (R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl-RuCl2 / methanol / 44 h / 60 °C / 64600 Torr
2: 90 percent / hexamethyldisiloxane; trimethylsilyl trifluoromethanesulfonate; triethylsilane / tetrahydrofuran / 0 - 20 °C
With
triethylsilane; dichloro-R-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl ruthenium; Hexamethyldisiloxane; trimethylsilyl trifluoromethanesulfonate; hydrogen;
In
tetrahydrofuran; methanol;
1: Noyori hydrogenation;
DOI:10.1016/j.tet.2004.10.017
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: pyridine / CH2Cl2 / 3.33 h / 0 - 20 °C
1.2: 46 percent / 6.5 h / Heating
2.1: 77 percent / hydrogen; (R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl-RuCl2 / methanol / 44 h / 60 °C / 64600 Torr
3.1: 90 percent / hexamethyldisiloxane; trimethylsilyl trifluoromethanesulfonate; triethylsilane / tetrahydrofuran / 0 - 20 °C
With
pyridine; triethylsilane; dichloro-R-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl ruthenium; Hexamethyldisiloxane; trimethylsilyl trifluoromethanesulfonate; hydrogen;
In
tetrahydrofuran; methanol; dichloromethane;
2.1: Noyori hydrogenation;
DOI:10.1016/j.tet.2004.10.017
