(3S,6R)-3-benzyl-6-(methoxymethyl)-3,6-dimethyl-5-phenyl-3H-1,4-oxazin-2(6H)-one

Base Information

• Chemical Name: (3S,6R)-3-benzyl-6-(methoxymethyl)-3,6-dimethyl-5-phenyl-3H-1,4-oxazin-2(6H)-one
• CAS No.: 1063964-53-3
• Molecular Formula: C₂₁H₂₃NO₃
• Molecular Weight: 337.419
• Mol file: 1063964-53-3.mol

Synonyms:(3S,6R)-3-benzyl-6-(methoxymethyl)-3,6-dimethyl-5-phenyl-3H-1,4-oxazin-2(6H)-one

Chemical Property of (3S,6R)-3-benzyl-6-(methoxymethyl)-3,6-dimethyl-5-phenyl-3H-1,4-oxazin-2(6H)-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (3S,6R)-3-benzyl-6-(methoxymethyl)-3,6-dimethyl-5-phenyl-3H-1,4-oxazin-2(6H)-one

There total 1 articles about (3S,6R)-3-benzyl-6-(methoxymethyl)-3,6-dimethyl-5-phenyl-3H-1,4-oxazin-2(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(3RS,6R)-3-benzyl-6-(methoxymethyl)-6-methyl-5-phenyl-3H-1,4-oxazin-2(6H)-one (1063964-42-0) + methyl iodide (74-88-4) → (3R,6R)-3-benzyl-6-(methoxymethyl)-3,6-dimethyl-5-phenyl-3H-1,4-oxazin-2(6H)-one (1063964-44-2) + (3S,6R)-3-benzyl-6-(methoxymethyl)-3,6-dimethyl-5-phenyl-3H-1,4-oxazin-2(6H)-one (1063964-53-3)

Guidance literature:

(3RS,6R)-3-benzyl-6-(methoxymethyl)-6-methyl-5-phenyl-3H-1,4-oxazin-2(6H)-one; With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at -78 ℃; optical yield given as %de; Inert atmosphere;

DOI:10.1021/jo801514g

Reference yield: 91.0%

(3S,6R)-3-benzyl-6-(methoxymethyl)-3,6-dimethyl-5-phenyl-3H-1,4-oxazin-2(6H)-one (1063964-53-3) → (S)-α-methyl-phenylalanine hydrochloride (30990-90-0)

Guidance literature:

With hydrogenchloride; water; at 90 ℃; for 1h; optical yield given as %ee;

DOI:10.1021/jo801514g

upstream raw materials:

(3RS,6R)-3-benzyl-6-(methoxymethyl)-6-methyl-5-phenyl-3H-1,4-oxazin-2(6H)-one

methyl iodide

Downstream raw materials:

(S)-α-methyl-phenylalanine hydrochloride