(3RS,6R)-3-benzyl-6-(methoxymethyl)-6-methyl-5-phenyl-3H-1,4-oxazin-2(6H)-one

Base Information

Chemical Name:(3RS,6R)-3-benzyl-6-(methoxymethyl)-6-methyl-5-phenyl-3H-1,4-oxazin-2(6H)-one
CAS No.:1063964-42-0
Molecular Formula:C₂₀H₂₁NO₃
Molecular Weight:323.392
Hs Code.:

Synonyms:(3RS,6R)-3-benzyl-6-(methoxymethyl)-6-methyl-5-phenyl-3H-1,4-oxazin-2(6H)-one

Suppliers and Price of (3RS,6R)-3-benzyl-6-(methoxymethyl)-6-methyl-5-phenyl-3H-1,4-oxazin-2(6H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (3RS,6R)-3-benzyl-6-(methoxymethyl)-6-methyl-5-phenyl-3H-1,4-oxazin-2(6H)-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (3RS,6R)-3-benzyl-6-(methoxymethyl)-6-methyl-5-phenyl-3H-1,4-oxazin-2(6H)-one

There total 1 articles about (3RS,6R)-3-benzyl-6-(methoxymethyl)-6-methyl-5-phenyl-3H-1,4-oxazin-2(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1063964-36-2
(S)-2-hydroxy-3-methoxy-2-methyl-1-phenylpropan-1-one

: 150-30-1,25191-15-5,658-69-5,67675-33-6
Phenylalanine

: 1063964-42-0
(3RS,6R)-3-benzyl-6-(methoxymethyl)-6-methyl-5-phenyl-3H-1,4-oxazin-2(6H)-one

Guidance literature:: (S)-2-hydroxy-3-methoxy-2-methyl-1-phenylpropan-1-one; Phenylalanine; With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃;

With hydrogenchloride; In toluene; at 20 ℃;

With potassium carbonate; In acetonitrile; at 20 ℃; for 18h;
DOI:10.1021/jo801514g

Reference yield: 90.0%

: 1063964-42-0
(3RS,6R)-3-benzyl-6-(methoxymethyl)-6-methyl-5-phenyl-3H-1,4-oxazin-2(6H)-one

: 590-17-0
cyanomethyl bromide

: 1063964-58-8
2-[(3R,6R)-3-benzyl-3,6-dihydro-6-(methoxymethyl)-6-methyl-2-oxo-5-phenyl-2H-1,4-oxazin-3-yl]acetonitrile

: 1063964-60-2
2-[(3S,6R)-3-benzyl-3,6-dihydro-6-(methoxymethyl)-6-methyl-2-oxo-5-phenyl-2H-1,4-oxazin-3-yl]acetonitrile

Guidance literature:: (3RS,6R)-3-benzyl-6-(methoxymethyl)-6-methyl-5-phenyl-3H-1,4-oxazin-2(6H)-one; With N,N'-dimethylpropylene urea; lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

cyanomethyl bromide; In tetrahydrofuran; at -78 ℃; optical yield given as %de; Inert atmosphere;
DOI:10.1021/jo801514g

Reference yield: 83.0%

: 1063964-42-0
(3RS,6R)-3-benzyl-6-(methoxymethyl)-6-methyl-5-phenyl-3H-1,4-oxazin-2(6H)-one

: 75-03-6
ethyl iodide

: 1063964-55-5
(3S,6R)-3-benzyl-3-ethyl-6-(methoxymethyl)-6-dimethyl-5-phenyl-3H-1,4-oxazin-2(6H)-one

: 1063964-56-6
(3R,6R)-3-benzyl-3-ethyl-6-(methoxymethyl)-6-dimethyl-5-phenyl-3H-1,4-oxazin-2(6H)-one

Guidance literature:: (3RS,6R)-3-benzyl-6-(methoxymethyl)-6-methyl-5-phenyl-3H-1,4-oxazin-2(6H)-one; With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

ethyl iodide; In tetrahydrofuran; at -78 ℃; optical yield given as %de; Inert atmosphere;
DOI:10.1021/jo801514g