3-((1-(N-(benzyloxycarbonyl)amino)-2-phenylethyl)(methyloxy)phosphinyl)propanoic acid ethyl ester

Base Information

• Chemical Name: 3-((1-(N-(benzyloxycarbonyl)amino)-2-phenylethyl)(methyloxy)phosphinyl)propanoic acid ethyl ester
• CAS No.: 372983-75-0
• Molecular Formula: C₂₂H₂₈NO₆P
• Molecular Weight: 433.441
• Mol file: 372983-75-0.mol

Synonyms:3-((1-(N-(benzyloxycarbonyl)amino)-2-phenylethyl)(methyloxy)phosphinyl)propanoic acid ethyl ester

Chemical Property of 3-((1-(N-(benzyloxycarbonyl)amino)-2-phenylethyl)(methyloxy)phosphinyl)propanoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-((1-(N-(benzyloxycarbonyl)amino)-2-phenylethyl)(methyloxy)phosphinyl)propanoic acid ethyl ester

There total 1 articles about 3-((1-(N-(benzyloxycarbonyl)amino)-2-phenylethyl)(methyloxy)phosphinyl)propanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(R,S)-3-((1'-(N-benzyloxycarbonylamino)-2'-phenylethyl)methyloxyphosphinyl)propanoic acid ethyl ester (181506-69-4) + phosphorous acid trimethyl ester (121-45-9) → 3-((1-(N-(benzyloxycarbonyl)amino)-2-phenylethyl)(methyloxy)phosphinyl)propanoic acid ethyl ester (372983-75-0)

Guidance literature:

at 90 ℃; for 10h;

DOI:10.1021/jo401084v

Reference yield: 89.0%

3-((1-(N-(benzyloxycarbonyl)amino)-2-phenylethyl)(methyloxy)phosphinyl)propanoic acid ethyl ester (372983-75-0) → 3-((1-(N-(benzyloxycarbonyl)amino)-2-phenylethyl)(methyloxy)thiophosphinyl)propanoic acid ethyl ester

Guidance literature:

With Lawessons reagent; In toluene; at 95 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jo401084v

Reference yield:

3-((1-(N-(benzyloxycarbonyl)amino)-2-phenylethyl)(methyloxy)phosphinyl)propanoic acid ethyl ester (372983-75-0) → 3-((1-(N-(benzyloxycarbonyl)amino)-2-phenylethyl)(methyloxy)thiophosphinyl)propanoic acid

Guidance literature:

Multi-step reaction with 2 steps

1: Lawessons reagent / toluene / 2 h / 95 °C / Inert atmosphere

2: sodium hydroxide / methanol; water / 1 h / 20 °C

With Lawessons reagent; sodium hydroxide; In methanol; water; toluene;

DOI:10.1021/jo401084v

upstream raw materials:

(R,S)-3-((1'-(N-benzyloxycarbonylamino)-2'-phenylethyl)methyloxyphosphinyl)propanoic acid ethyl ester

phosphorous acid trimethyl ester