5-(3-ethoxycarbonylamino-2-fluoro-phenyl)-pentanoic acid methyl ester

Base Information

• Chemical Name: 5-(3-ethoxycarbonylamino-2-fluoro-phenyl)-pentanoic acid methyl ester
• CAS No.: 741721-39-1
• Molecular Formula: C₁₅H₂₀FNO₄
• Molecular Weight: 297.327
• Mol file: 741721-39-1.mol

Synonyms:5-(3-ethoxycarbonylamino-2-fluoro-phenyl)-pentanoic acid methyl ester

Chemical Property of 5-(3-ethoxycarbonylamino-2-fluoro-phenyl)-pentanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(3-ethoxycarbonylamino-2-fluoro-phenyl)-pentanoic acid methyl ester

There total 4 articles about 5-(3-ethoxycarbonylamino-2-fluoro-phenyl)-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

5-(3-amino-2-fluoro-phenyl)-pentanoic acid methyl ester (914257-38-8) + chloroformic acid ethyl ester (541-41-3) → 5-(3-ethoxycarbonylamino-2-fluoro-phenyl)-pentanoic acid methyl ester (741721-39-1)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

5-(2-fluoro-3-nitro-phenyl)-pent-4-ynoic acid methyl ester (741721-37-9) → 5-(3-ethoxycarbonylamino-2-fluoro-phenyl)-pentanoic acid methyl ester (741721-39-1)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C / methanol

2: i-Pr₂NH / CH₂Cl₂

With hydrogen; diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1016/j.bmcl.2006.07.064

Reference yield:

4-pentynoic acid (6089-09-4) → 5-(3-ethoxycarbonylamino-2-fluoro-phenyl)-pentanoic acid methyl ester (741721-39-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 75 percent / sulfuric acid

2: Pd(OAc)2; PPh₃; CuI / HNEt₂ / dimethylformamide

3: H₂ / Pd/C / methanol

4: i-Pr₂NH / CH₂Cl₂

With palladium diacetate; copper(l) iodide; sulfuric acid; hydrogen; diisopropylamine; triphenylphosphine; palladium on activated charcoal; diethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; 2: Sonagashira coupling;

DOI:10.1016/j.bmcl.2006.07.064

upstream raw materials:

5-(3-amino-2-fluoro-phenyl)-pentanoic acid methyl ester

chloroformic acid ethyl ester

5-(2-fluoro-3-nitro-phenyl)-pent-4-ynoic acid methyl ester

4-pentynoic acid

Downstream raw materials:

5-(3-ethoxycarbonylamino-2-fluoro-phenyl)-pentanoic acid