4-(5-((2,4-dioxo-3,4-dihydroquinazoline-1(2H)-yl)methyl)-2-fluorobenzoyl)-piperazine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-(5-((2,4-dioxo-3,4-dihydroquinazoline-1(2H)-yl)methyl)-2-fluorobenzoyl)-piperazine-1-carboxylic acid tert-butyl ester
CAS No.:1399119-69-7
Molecular Formula:C₂₅H₂₇FN₄O₅
Molecular Weight:482.512
Hs Code.:

Synonyms:4-(5-((2,4-dioxo-3,4-dihydroquinazoline-1(2H)-yl)methyl)-2-fluorobenzoyl)-piperazine-1-carboxylic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(5-((2,4-dioxo-3,4-dihydroquinazoline-1(2H)-yl)methyl)-2-fluorobenzoyl)-piperazine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-(5-((2,4-dioxo-3,4-dihydroquinazoline-1(2H)-yl)methyl)-2-fluorobenzoyl)-piperazine-1-carboxylic acid tert-butyl ester

There total 11 articles about 4-(5-((2,4-dioxo-3,4-dihydroquinazoline-1(2H)-yl)methyl)-2-fluorobenzoyl)-piperazine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.7%

: 1399119-66-4
5-((2,4-dioxo-3,4-dihydroquinazoline-1(2H)-yl)methyl)-2-fluorobenzoic acid

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1399119-69-7
4-(5-((2,4-dioxo-3,4-dihydroquinazoline-1(2H)-yl)methyl)-2-fluorobenzoyl)-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: 5-((2,4-dioxo-3,4-dihydroquinazoline-1(2H)-yl)methyl)-2-fluorobenzoic acid; With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

1-t-Butoxycarbonylpiperazine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: C₂₀H₁₉FN₂O₄

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1399119-69-7
4-(5-((2,4-dioxo-3,4-dihydroquinazoline-1(2H)-yl)methyl)-2-fluorobenzoyl)-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In acetonitrile; at 20 ℃; for 2h;

Reference yield:

: 118-48-9
isatoic anhydride

: 1399119-69-7
4-(5-((2,4-dioxo-3,4-dihydroquinazoline-1(2H)-yl)methyl)-2-fluorobenzoyl)-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: dmap / N,N-dimethyl-formamide / 4.5 h / 20 °C

2.1: sodium hydroxide / 1,4-dioxane / 5 h / 20 °C / Cooling with ice

3.1: potassium hydroxide / ethanol / 16 h / Reflux

3.2: 20 °C / pH 3 - 4

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Cooling with ice

4.2: 3 h / 20 °C / Cooling with ice

5.1: hydrogenchloride / 1,4-dioxane / Reflux

5.2: 3 h / 20 °C / pH > 13

5.3: pH < 2

6.1: N-ethyl-N,N-diisopropylamine; HATU / acetonitrile / 2 h / 20 °C

With hydrogenchloride; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; sodium hydroxide; dmap; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide; acetonitrile; mineral oil;