(E)-(2R,3S)-6-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxy-2-methyl-hex-4-enoic acid methoxy-methyl-amide

Base Information

Chemical Name:(E)-(2R,3S)-6-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxy-2-methyl-hex-4-enoic acid methoxy-methyl-amide
CAS No.:455901-49-2
Molecular Formula:C₂₅H₃₅NO₄Si
Molecular Weight:441.643
Hs Code.:

Synonyms:(E)-(2R,3S)-6-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxy-2-methyl-hex-4-enoic acid methoxy-methyl-amide

Suppliers and Price of (E)-(2R,3S)-6-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxy-2-methyl-hex-4-enoic acid methoxy-methyl-amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-(2R,3S)-6-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxy-2-methyl-hex-4-enoic acid methoxy-methyl-amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-(2R,3S)-6-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxy-2-methyl-hex-4-enoic acid methoxy-methyl-amide

There total 3 articles about (E)-(2R,3S)-6-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxy-2-methyl-hex-4-enoic acid methoxy-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1117-97-1
N,0-dimethylhydroxylamine

: 455901-38-9
(4E)-1-[(4R)-2-oxo-4-benzyl(1,3-oxazolidin-3-yl)](3S,2R)-6-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-3-hydroxy-2-methylhex-4-en-1-one

: 455901-49-2
(E)-(2R,3S)-6-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxy-2-methyl-hex-4-enoic acid methoxy-methyl-amide

Guidance literature:: With trimethylaluminum; In tetrahydrofuran;
DOI:10.1002/1521-3773(20020517)41:10<1737::AID-ANIE1737>3.0.CO;2-4

Reference yield:

: 131380-48-8
(E)-4-(t-butyldiphenylsilyl)oxy-2-butenal

: 455901-49-2
(E)-(2R,3S)-6-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxy-2-methyl-hex-4-enoic acid methoxy-methyl-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: Bu₂BOTf; TEA / CH₂Cl₂ / 0 °C

1.2: 89 percent / CH₂Cl₂ / -78 - 0 °C

2.1: 97 percent / Me₃Al / tetrahydrofuran / -78 - 0 °C

With di-n-butylboryl trifluoromethanesulfonate; TEA; trimethylaluminum; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja037643+

Reference yield:

: 87770-83-0
(Z)-4-((tert-butyldiphenylsilyl)oxy)but-2-en-1-ol

: 455901-49-2
(E)-(2R,3S)-6-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxy-2-methyl-hex-4-enoic acid methoxy-methyl-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 6.35 g / Et₃N; SO₃; pyridine / CH₂Cl₂; dimethylsulfoxide / 0 - 20 °C

2.1: Bu₂BOTf; TEA / CH₂Cl₂ / 0 °C

2.2: 89 percent / CH₂Cl₂ / -78 - 0 °C

3.1: 97 percent / Me₃Al / tetrahydrofuran / -78 - 0 °C

With pyridine; di-n-butylboryl trifluoromethanesulfonate; TEA; sulfur trioxide; trimethylaluminum; triethylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/ja037643+