4-(5-(naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-ynyl 4-fluorobenzoate

Base Information

Chemical Name:4-(5-(naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-ynyl 4-fluorobenzoate
CAS No.:844459-93-4
Molecular Formula:C₂₃H₁₅FN₂O₃S
Molecular Weight:418.448
Hs Code.:

Synonyms:4-(5-(naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-ynyl 4-fluorobenzoate

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Chemical Property of 4-(5-(naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-ynyl 4-fluorobenzoate

Chemical Property:

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Technology Process of 4-(5-(naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-ynyl 4-fluorobenzoate

There total 3 articles about 4-(5-(naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-ynyl 4-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 456-22-4
4-Fluorobenzoic acid

: 727385-55-9
4-(5-(naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-yn-1-ol

: 844459-93-4
4-(5-(naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-ynyl 4-fluorobenzoate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 25 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm1008852

Reference yield:

: 43038-45-5
1-naphthohydrazide

: 844459-93-4
4-(5-(naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-ynyl 4-fluorobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / ethanol / 10.17 h / 25 °C / Reflux; Inert atmosphere

2: potassium carbonate / acetone / 1 h / 40 °C / Inert atmosphere

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 4 h / 25 °C / Inert atmosphere

With dmap; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In ethanol; N,N-dimethyl-formamide; acetone;

Reference yield:

: 116082-89-4
5-(naphthalen-1-yl)-1,3,4-oxadiazole-2-thiol

: 844459-93-4
4-(5-(naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-ynyl 4-fluorobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 1 h / 40 °C / Inert atmosphere

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 4 h / 25 °C / Inert atmosphere

With dmap; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; acetone;