4-(5-(naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-yn-1-ol

Base Information

• Chemical Name: 4-(5-(naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-yn-1-ol
• CAS No.: 727385-55-9
• Molecular Formula: C₁₆H₁₂N₂O₂S
• Molecular Weight: 296.349
• Mol file: 727385-55-9.mol

Synonyms:4-(5-(naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-yn-1-ol

Chemical Property of 4-(5-(naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-yn-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(5-(naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-yn-1-ol

There total 2 articles about 4-(5-(naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-yn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chlorobut-2-yn-1-ol (13280-07-4) + 5-(naphthalen-1-yl)-1,3,4-oxadiazole-2-thiol (116082-89-4) → 4-(5-(naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-yn-1-ol (727385-55-9)

Guidance literature:

With potassium carbonate; In acetone; for 1h; Inert atmosphere; Reflux;

DOI:10.1021/jm1008852

Reference yield:

1-naphthohydrazide (43038-45-5) → 4-(5-(naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-yn-1-ol (727385-55-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 10.17 h / 25 °C / Reflux; Inert atmosphere

2: potassium carbonate / acetone / 1 h / 40 °C / Inert atmosphere

With potassium carbonate; potassium hydroxide; In ethanol; acetone;

Reference yield:

4-Fluorobenzoic acid (456-22-4) + 4-(5-(naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-yn-1-ol (727385-55-9) → 4-(5-(naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-ynyl 4-fluorobenzoate (844459-93-4)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 25 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jm1008852

upstream raw materials:

4-chlorobut-2-yn-1-ol

5-(naphthalen-1-yl)-1,3,4-oxadiazole-2-thiol

1-naphthohydrazide

Downstream raw materials:

4-(5-(naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-ynyl 4-fluorobenzoate

C₂₃H₁₅BrN₂O₃S

C₂₄H₁₅F₃N₂O₃S

4-(5-(naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-ynyl 4-(trifluoromethyl)benzoate