3-(sulfooxy)propyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate sodium salt

Base Information

Chemical Name:3-(sulfooxy)propyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate sodium salt
CAS No.:1268383-55-6
Molecular Formula:C₂₉H₂₃F₅N₅O₈S*Na
Molecular Weight:719.578
Hs Code.:

3-(sulfooxy)propyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate sodium salt

Synonyms:3-(sulfooxy)propyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate sodium salt

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Chemical Property of 3-(sulfooxy)propyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate sodium salt

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Technology Process of 3-(sulfooxy)propyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate sodium salt

There total 9 articles about 3-(sulfooxy)propyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1268385-18-7
3-(sulfooxy)propyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

: 1268383-55-6
3-(sulfooxy)propyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate sodium salt

Guidance literature:: With sodium hydrogencarbonate; In water; acetonitrile;

Reference yield:

: 1234790-83-0
4-(propyloxy)-2-(trifluoromethyl)benzaldehyde oxime

: 1268383-55-6
3-(sulfooxy)propyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate sodium salt

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0 °C

1.2: Reflux

2.1: periodic acid / acetonitrile / 0 - 20 °C

2.2: 0 - 20 °C

3.1: thionyl chloride / 20 °C

4.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 5 h / Reflux; Inert atmosphere

5.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

6.1: potassium carbonate / 1,2-dimethoxyethane / 5 h / 20 °C

7.1: sulfur trioxide pyridine complex / N,N-dimethyl-formamide / 2 h / 20 °C

8.1: sodium hydrogencarbonate / acetonitrile; water

With N-chloro-succinimide; N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); sulfur trioxide pyridine complex; sodium hydrogencarbonate; potassium carbonate; periodic acid; In tetrachloromethane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1268383-45-4
3-hydroxypropyl 2-(2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl)-2-(3-(4-propoxy-2-(trifluoromethyl)phenyl)isoxazol-5-yl)acetate

: 1268383-55-6
3-(sulfooxy)propyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate sodium salt

Guidance literature:: Multi-step reaction with 2 steps

1: sulfur trioxide pyridine complex / N,N-dimethyl-formamide / 2 h / 20 °C

2: sodium hydrogencarbonate / acetonitrile; water

With sulfur trioxide pyridine complex; sodium hydrogencarbonate; In water; N,N-dimethyl-formamide; acetonitrile;