3-hydroxypropyl 2-(2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl)-2-(3-(4-propoxy-2-(trifluoromethyl)phenyl)isoxazol-5-yl)acetate

Base Information

Chemical Name:3-hydroxypropyl 2-(2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl)-2-(3-(4-propoxy-2-(trifluoromethyl)phenyl)isoxazol-5-yl)acetate
CAS No.:1268383-45-4
Molecular Formula:C₂₉H₂₄F₅N₅O₅
Molecular Weight:617.532
Hs Code.:

Synonyms:3-hydroxypropyl 2-(2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl)-2-(3-(4-propoxy-2-(trifluoromethyl)phenyl)isoxazol-5-yl)acetate

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Chemical Property of 3-hydroxypropyl 2-(2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl)-2-(3-(4-propoxy-2-(trifluoromethyl)phenyl)isoxazol-5-yl)acetate

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Technology Process of 3-hydroxypropyl 2-(2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl)-2-(3-(4-propoxy-2-(trifluoromethyl)phenyl)isoxazol-5-yl)acetate

There total 15 articles about 3-hydroxypropyl 2-(2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl)-2-(3-(4-propoxy-2-(trifluoromethyl)phenyl)isoxazol-5-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1268383-41-0
methyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-acetate

: 504-63-2
trimethyleneglycol

: 1268383-45-4
3-hydroxypropyl 2-(2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl)-2-(3-(4-propoxy-2-(trifluoromethyl)phenyl)isoxazol-5-yl)acetate

Guidance literature:: With potassium carbonate; In 1,2-dimethoxyethane; at 20 ℃; for 5h;

Reference yield:

: 1268385-32-5
2-{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-ethanol

: 1268383-45-4
3-hydroxypropyl 2-(2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl)-2-(3-(4-propoxy-2-(trifluoromethyl)phenyl)isoxazol-5-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: periodic acid / acetonitrile / 0 - 20 °C

1.2: 0 - 20 °C

2.1: thionyl chloride / 20 °C

3.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 5 h / Reflux; Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

5.1: potassium carbonate / 1,2-dimethoxyethane / 5 h / 20 °C

With N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); potassium carbonate; periodic acid; In tetrachloromethane; 1,2-dimethoxyethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1234790-81-8
4-(propyloxy)-2-(trifluoromethyl)benzaldehyde

: 1268383-45-4
3-hydroxypropyl 2-(2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl)-2-(3-(4-propoxy-2-(trifluoromethyl)phenyl)isoxazol-5-yl)acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydroxylamine / ethanol; water / 2 h / 20 °C

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0 °C

2.2: Reflux

3.1: periodic acid / acetonitrile / 0 - 20 °C

3.2: 0 - 20 °C

4.1: thionyl chloride / 20 °C

5.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 5 h / Reflux; Inert atmosphere

6.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

7.1: potassium carbonate / 1,2-dimethoxyethane / 5 h / 20 °C

With N-chloro-succinimide; N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); hydroxylamine; potassium carbonate; periodic acid; In tetrachloromethane; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; acetonitrile;