(4S)-4-[1'-(2'',3'',5'',6''-tetrafluorobenzyloxy)-1'-methyl-ethyl]-2-(2'''-diphenylphosphanylphenyl)-4,5-dihydrooxazole

Base Information

Chemical Name:(4S)-4-[1'-(2'',3'',5'',6''-tetrafluorobenzyloxy)-1'-methyl-ethyl]-2-(2'''-diphenylphosphanylphenyl)-4,5-dihydrooxazole
CAS No.:1301708-37-1
Molecular Formula:C₃₁H₂₆F₄NO₂P
Molecular Weight:551.52
Hs Code.:

Synonyms:(4S)-4-[1'-(2'',3'',5'',6''-tetrafluorobenzyloxy)-1'-methyl-ethyl]-2-(2'''-diphenylphosphanylphenyl)-4,5-dihydrooxazole

Suppliers and Price of (4S)-4-[1'-(2'',3'',5'',6''-tetrafluorobenzyloxy)-1'-methyl-ethyl]-2-(2'''-diphenylphosphanylphenyl)-4,5-dihydrooxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4S)-4-[1'-(2'',3'',5'',6''-tetrafluorobenzyloxy)-1'-methyl-ethyl]-2-(2'''-diphenylphosphanylphenyl)-4,5-dihydrooxazole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4S)-4-[1'-(2'',3'',5'',6''-tetrafluorobenzyloxy)-1'-methyl-ethyl]-2-(2'''-diphenylphosphanylphenyl)-4,5-dihydrooxazole

There total 6 articles about (4S)-4-[1'-(2'',3'',5'',6''-tetrafluorobenzyloxy)-1'-methyl-ethyl]-2-(2'''-diphenylphosphanylphenyl)-4,5-dihydrooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 53001-73-3
3-(bromomethyl)-1,2,4,5-tetrafluorobenzene

: (4'S)-2-[2'-(2''-diphenylphosphanylphenyl)-4',5'-dihydro-oxazol-4'-yl]-propan-2-ol

: 1301708-37-1
(4S)-4-[1'-(2'',3'',5'',6''-tetrafluorobenzyloxy)-1'-methyl-ethyl]-2-(2'''-diphenylphosphanylphenyl)-4,5-dihydrooxazole

Guidance literature:: (4'S)-2-[2'-(2''-diphenylphosphanylphenyl)-4',5'-dihydro-oxazol-4'-yl]-propan-2-ol; With potassium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere;

3-(bromomethyl)-1,2,4,5-tetrafluorobenzene; In tetrahydrofuran; at 20 ℃; for 23h; Inert atmosphere;
DOI:10.1002/chem.201003314

Reference yield:

: 393-52-2
2-Fluorobenzoyl chloride

: 1301708-37-1
(4S)-4-[1'-(2'',3'',5'',6''-tetrafluorobenzyloxy)-1'-methyl-ethyl]-2-(2'''-diphenylphosphanylphenyl)-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / methanol / 2.75 h / 0 °C / Inert atmosphere

2.1: tetrahydrofuran; diethyl ether / 19.17 h / 0 - 20 °C / Inert atmosphere

2.2: 0 °C

3.1: triethylamine; p-toluenesulfonyl chloride / dichloromethane / 75 h / 20 °C / Inert atmosphere

4.1: tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

5.1: potassium hydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

5.2: 23 h / 20 °C / Inert atmosphere

With potassium hydride; triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1002/chem.201003314

Reference yield:

: 179117-11-4
(1'S)-2-fluoro-N-(2'-hydroxy-1'-hydroxymethyl-2'-methylpropyl)-benzamide

: 1301708-37-1
(4S)-4-[1'-(2'',3'',5'',6''-tetrafluorobenzyloxy)-1'-methyl-ethyl]-2-(2'''-diphenylphosphanylphenyl)-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; p-toluenesulfonyl chloride / dichloromethane / 75 h / 20 °C / Inert atmosphere

2.1: tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

3.1: potassium hydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

3.2: 23 h / 20 °C / Inert atmosphere

With potassium hydride; triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1002/chem.201003314