ethyl 3-(cyclopropylmethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

Base Information

Chemical Name:ethyl 3-(cyclopropylmethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate
CAS No.:1229442-64-1
Molecular Formula:C₁₉H₂₇BO₅
Molecular Weight:346.231
Hs Code.:

Synonyms:ethyl 3-(cyclopropylmethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

Suppliers and Price of ethyl 3-(cyclopropylmethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 3-(cyclopropylmethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 3-(cyclopropylmethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

There total 7 articles about ethyl 3-(cyclopropylmethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1229442-64-1
ethyl 3-(cyclopropylmethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

Guidance literature:

Reference yield:

: 6307-83-1
3-bromo-5-nitro-benzoic acid

: 1229442-64-1
ethyl 3-(cyclopropylmethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

: (3-(cyclopropylmethoxy)-5-(ethoxycarbonyl)phenyl)boronic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / ethanol; water / 0.08 h / 20 °C

1.2: 2 h / 50 °C

2.1: water; sulfuric acid; sodium nitrite / 1.67 h / Reflux

3.1: sulfuric acid / 5 h / 90 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 100 °C

5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / dimethyl sulfoxide / 4 h / 80 °C / Schlenk technique; Inert atmosphere

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; water; potassium acetate; potassium carbonate; sodium nitrite; In ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.6b00829

Reference yield:

: 1229442-63-0
ethyl 3-bromo-5-(cyclopropylmethoxy)benzoate

: 73183-34-3
bis(pinacol)diborane

: 1229442-64-1
ethyl 3-(cyclopropylmethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

: (3-(cyclopropylmethoxy)-5-(ethoxycarbonyl)phenyl)boronic acid

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In dimethyl sulfoxide; at 80 ℃; for 4h; Overall yield = 920 mg; Schlenk technique; Inert atmosphere;
DOI:10.1021/acs.jmedchem.6b00829