2-furan-2-yl-7-(3-piperazin-1-yl-phenyl)-[1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine

Base Information

Chemical Name:2-furan-2-yl-7-(3-piperazin-1-yl-phenyl)-[1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine
CAS No.:540752-08-7
Molecular Formula:C₁₉H₁₉N₇O
Molecular Weight:361.406
Hs Code.:

2-furan-2-yl-7-(3-piperazin-1-yl-phenyl)-[1,2,4]triazolo[1,5-<i>c</i>]pyrimidin-5-ylamine

Synonyms:2-furan-2-yl-7-(3-piperazin-1-yl-phenyl)-[1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine

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Chemical Property of 2-furan-2-yl-7-(3-piperazin-1-yl-phenyl)-[1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine

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Technology Process of 2-furan-2-yl-7-(3-piperazin-1-yl-phenyl)-[1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine

There total 7 articles about 2-furan-2-yl-7-(3-piperazin-1-yl-phenyl)-[1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 540751-83-5
4-[3-(5-amino-2-furan-2-yl-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester

: 540752-08-7
2-furan-2-yl-7-(3-piperazin-1-yl-phenyl)-[1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane;
DOI:10.1016/j.bmcl.2005.05.043

Reference yield:

: 198627-86-0
1,1-dimethylethyl 4-(3-hydroxyphenyl)-1-piperazinecarboxylate

: 540752-08-7
2-furan-2-yl-7-(3-piperazin-1-yl-phenyl)-[1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 80 percent / Et₃N / CH₂Cl₂

2.1: 82 percent / PdCl₂ (dppf); dppf; KOAc / dioxane

3.1: 70 percent / Pd(PPh₃); aq. K₂CO₃ / acetonitrile

4.1: butan-1-ol

4.2: N,O-bis(trimethylsilyl)acetamide (BSA)

5.1: 73 percent / HCl / dioxane

With hydrogenchloride; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; Pd(PPh₃); potassium acetate; potassium carbonate; triethylamine; In 1,4-dioxane; dichloromethane; acetonitrile; butan-1-ol;
DOI:10.1016/j.bmcl.2005.05.043

Reference yield:

: 540752-86-1
4-(3-trifluoromethanesulfonyloxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

: 540752-08-7
2-furan-2-yl-7-(3-piperazin-1-yl-phenyl)-[1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 82 percent / PdCl₂ (dppf); dppf; KOAc / dioxane

2.1: 70 percent / Pd(PPh₃); aq. K₂CO₃ / acetonitrile

3.1: butan-1-ol

3.2: N,O-bis(trimethylsilyl)acetamide (BSA)

4.1: 73 percent / HCl / dioxane

With hydrogenchloride; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; Pd(PPh₃); potassium acetate; potassium carbonate; In 1,4-dioxane; acetonitrile; butan-1-ol;
DOI:10.1016/j.bmcl.2005.05.043