N-cyclopropyl-4-{6-(3-fluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-a]pyridin-3-yl}-2-methylbenzamid

Base Information

Chemical Name:N-cyclopropyl-4-{6-(3-fluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-a]pyridin-3-yl}-2-methylbenzamid
CAS No.:1402593-77-4
Molecular Formula:C₂₈H₂₆F₄N₄O₃
Molecular Weight:542.533
Hs Code.:

Synonyms:N-cyclopropyl-4-{6-(3-fluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-a]pyridin-3-yl}-2-methylbenzamid

Suppliers and Price of N-cyclopropyl-4-{6-(3-fluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-a]pyridin-3-yl}-2-methylbenzamid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-cyclopropyl-4-{6-(3-fluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-a]pyridin-3-yl}-2-methylbenzamid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-cyclopropyl-4-{6-(3-fluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-a]pyridin-3-yl}-2-methylbenzamid

There total 8 articles about N-cyclopropyl-4-{6-(3-fluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-a]pyridin-3-yl}-2-methylbenzamid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1402595-17-8
4-{6-bromo-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-a]pyridin-3-yl}-N-cyclopropyl-2-methylbenzamide

: 452-11-9
3-fluoro-4-methoxyphenol

: 1402593-77-4
N-cyclopropyl-4-{6-(3-fluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-a]pyridin-3-yl}-2-methylbenzamid

Guidance literature:: With pyrrolidine-2-phosphonic acid phenyl monoester; caesium carbonate; copper(l) chloride; In 1,4-dioxane; at 130 ℃; for 4h; Microwave irradiation;

Reference yield:

: 68837-59-2
4-bromo-2-methylbenzoic acid

: 1402593-77-4
N-cyclopropyl-4-{6-(3-fluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-a]pyridin-3-yl}-2-methylbenzamid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

2.1: potassium acetate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 6 h / Reflux

3.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 20 - 80 °C

4.1: 1,1-dichloroethane / 2 h / 20 °C

4.2: 1 h

5.1: caesium carbonate; copper(l) chloride; pyrrolidine-2-phosphonic acid phenyl monoester / 1,4-dioxane / 4 h / 130 °C / Microwave irradiation

With pyrrolidine-2-phosphonic acid phenyl monoester; potassium acetate; potassium carbonate; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; copper(l) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tetrahydrofuran; 1,4-dioxane; 1,1-dichloroethane; dichloromethane; water;

Reference yield:

: 38875-53-5
5-bromo-pyridine-2,3-diamine

: 1402593-77-4
N-cyclopropyl-4-{6-(3-fluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-a]pyridin-3-yl}-2-methylbenzamid

Guidance literature:: Multi-step reaction with 5 steps

1.1: isopropyl alcohol / 20 °C / Reflux; Inert atmosphere

2.1: N-iodo-succinimide / tetrahydrofuran / 0 °C

3.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 20 - 80 °C

4.1: 1,1-dichloroethane / 2 h / 20 °C

4.2: 1 h

5.1: caesium carbonate; copper(l) chloride; pyrrolidine-2-phosphonic acid phenyl monoester / 1,4-dioxane / 4 h / 130 °C / Microwave irradiation

With pyrrolidine-2-phosphonic acid phenyl monoester; N-iodo-succinimide; potassium carbonate; caesium carbonate; copper(l) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; 1,1-dichloroethane; water; isopropyl alcohol;