452-11-9

Basic information

• Product Name: 3-FLUORO-4-METHOXYPHENOL
• Synonyms: 3-FLUORO-4-METHOXYPHENOL;4-Aminomethyl-4-(3-bromo-phenyl)-piperidine-1-carboxylic acid tert-butyl ester;2-Fluoro-4-hydroxyanisole
• CAS NO: 452-11-9
• Molecular Formula: C₇H₇FO₂
• Molecular Weight: 142.13
• Product Categories: Phenol&Thiophenol&Mercaptan
• Mol File: 452-11-9.mol
• Article Data: 10

Chemical Properties

• Melting Point: 54-55 °C
• Boiling Point: 248.243 °C at 760 mmHg
• Flash Point: 121.424 °C
• Appearance: /
• Density: 1.224g/cm³
• Vapor Pressure: 0.016mmHg at 25°C
• Refractive Index: 1.512
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.46±0.18(Predicted)
• CAS DataBase Reference: 3-FLUORO-4-METHOXYPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUORO-4-METHOXYPHENOL(452-11-9)
• EPA Substance Registry System: 3-FLUORO-4-METHOXYPHENOL(452-11-9)

Safety Data

• Hazardous Substances Data: 452-11-9(Hazardous Substances Data)

Usage

Uses

3-Fluoro-4-methoxyphenol is used in the preparation of non-peptidic NPBWR1 (GPR7) antagonists.

InChI:InChI=1/C7H7FO2/c1-10-7-3-2-5(9)4-6(7)8/h2-4,9H,1H3

Upstream product

• 366-99-4 3-fluoro-4-methoxyaniline 
• 367-12-4 2-fluorophenol 
• 2357-52-0 3-fluoro-4-methoxyphenyl bromide 
• 351-54-2 3-fluoro-p-anisaldehyde 
• 34036-07-2 3,4 difluorobenzaldehyde 
• 946833-20-1 acetic acid 3-fluoro-4-methoxyphenyl ester 
• 455-93-6 2-fluoro-1-methoxy-4-nitrobenzene 
• 321-28-8 1-fluoro-2-methoxybenzene 

Downstream Products

• 1369628-59-0 1-(4-fluoro-2-hydroxy-5-methoxyphenyl)ethanone 
• 946833-20-1 acetic acid 3-fluoro-4-methoxyphenyl ester 
• 917925-60-1 4-(2-fluoro-3-methoxy-6-methoxymethoxy-benzoyl)-benzoic acid methyl ester 
• 133788-99-5 2-fluoro-1-methoxy-4-methoxymethoxy-benzene 
• 170795-17-2 2-[(3-Fluoro₄-methoxy)phenoxy]tetrahydropyran 
• 348-95-8 4-(3-fluoro-4-methoxy-phenoxy)-3,5-diiodo-aniline; hydrochloride 
• 127557-02-2 4-(3-Fluoro-4-methoxy-phenoxy)-butyric acid 
• 327-85-5 4-(2,6-diiodo-4-nitro-phenoxy)-2-fluoro-1-methoxy-benzene 

Relevant articles and documents

AMINATION AND HYDROXYLATION OF ARYLMETAL COMPOUNDS

In one aspect, the present disclosure provides methods of preparing a primary or secondary amine and hydroxylated aromatic compounds. In some embodiments, the aromatic compound may be unsubstituted, substituted, or contain one or more heteroatoms within the rings of the aromatic compound. The methods described herein may be carried out without the need for transition metal catalysts or harsh reaction conditions.

NOVEL NUCLEOSIDE PHOSPHORAMIDATE COMPOUND AND USE THEREOF

The present invention provides a novel nucleoside phosphoramidate compound, or a stereoisomer, salt, hydrate, solvate or crystal thereof for the treatment of Flaviviridae family viral infection, especially hepatitis C viral infection. The present invention also provides the pharmaceutical composition comprising a compound of the present invention, or a stereoisomer, salt, hydrate, solvate or crystal thereof and a use of the compound or the composition of the present invention in the treatment of Flaviviridae family viral infection, especially hepatitis C viral infection. The compound of the present invention has a good anti-HCV effect.

LABELED PKG-1-ALPHA-BINDING COMPOUNDS AND THEIR USE IN IMAGING AND QUANTIFYING PAIN

The present invention relates to the use of compounds that selectively bind to activated protein kinase G1 alpha for imaging the anatomic basis for chronic pain. Such imaging may also be used to objectively quantify chronic pain. Specifically, fluorine-18