Meglitinide

Base Information

• Chemical Name: Meglitinide
• CAS No.: 54870-28-9
• Molecular Formula: C17H16 Cl N O4
• Molecular Weight: 333.771
• Hs Code.: 2924299090
• UNII: 8V6OK1I088
• DSSTox Substance ID: DTXSID40203356
• Nikkaji Number: J11.927J
• Wikidata: Q27271068
• NCI Thesaurus Code: C66075
• ChEMBL ID: CHEMBL149930
• Mol file: 54870-28-9.mol

Synonyms:4-(2-(5-chloro-2-methoxybenzamido)ethyl)benzoic acid;HB 699;meglitinide

Chemical Property of Meglitinide

Chemical Property:

• Vapor Pressure: 2.43E-12mmHg at 25°C
• Boiling Point: 536.5°C at 760 mmHg
• Flash Point: 278.3°C
• PSA: 79.12000
• Density: 1.306g/cm³
• LogP: 3.59410
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 333.0767857
• Heavy Atom Count: 23
• Complexity: 409

Purity/Quality:

99% ^*data from raw suppliers

MEGLITINIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)C(=O)O
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Technology Process of Meglitinide

There total 4 articles about Meglitinide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

4-(2-amino-ethyl)-benzoic acid hydrochloride (60531-36-4) + 2-methoxy-5-chlorobenzoyl chloride (29568-33-0) → meglitinide (54870-28-9)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1039/c3md00214d

Reference yield: 37.0%

4-(2-aminoethyl)benzoic acid (1199-69-5) + 2-methoxy-5-chlorobenzoyl chloride (29568-33-0) → meglitinide (54870-28-9)

Guidance literature:

With sodium hydroxide; In acetone; for 2h;

DOI:10.1021/jm00367a016

Reference yield:

4-(2-<5-chloro-2-methoxy-benzamido>-ethyl)-acetophenone (60531-37-5) + DK13 (33924-49-1) → meglitinide (54870-28-9)

Guidance literature:

With bromine; In 1,1-dichloroethane; water;

upstream raw materials:

4-(2-aminoethyl)benzoic acid

2-methoxy-5-chlorobenzoyl chloride

4-(2-<5-chloro-2-methoxy-benzamido>-ethyl)-acetophenone

DK₁₃

Downstream raw materials:

4-(2-<5-Chloro-2-methoxy-benzamido>-ethyl)-benzoic acid propyl ester

4-(2-<5-chloro-2-methoxy-benzamido>-ethyl)-benzoic acid-isopropyl ester

4-(2-<5-chloro-2-methoxy-benzamido>-ethyl)-benzoic acid-n-butyl ester

2-(((4-(2-(5-chloro-2-methoxybenzamido)ethyl)benzoyl)oxy)-methoxy)-1-(pyrrolidin-1-yl)diazene oxide

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