2-[3-(N-phenylmethoxycarbonyl)amino-4-(2-phenylmethoxy-3,4-dimethoxy)phenyl-5-methyl-6-phenylmethoxy]-2-pyridinyl-6-methoxyquinoline-5,8-dione

Base Information

Chemical Name:2-[3-(N-phenylmethoxycarbonyl)amino-4-(2-phenylmethoxy-3,4-dimethoxy)phenyl-5-methyl-6-phenylmethoxy]-2-pyridinyl-6-methoxyquinoline-5,8-dione
CAS No.:957785-33-0
Molecular Formula:C₄₆H₃₉N₃O₉
Molecular Weight:777.83
Hs Code.:

2-[3-(N-phenylmethoxycarbonyl)amino-4-(2-phenylmethoxy-3,4-dimethoxy)phenyl-5-methyl-6-phenylmethoxy]-2-pyridinyl-6-methoxyquinoline-5,8-dione

Synonyms:2-[3-(N-phenylmethoxycarbonyl)amino-4-(2-phenylmethoxy-3,4-dimethoxy)phenyl-5-methyl-6-phenylmethoxy]-2-pyridinyl-6-methoxyquinoline-5,8-dione

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Chemical Property of 2-[3-(N-phenylmethoxycarbonyl)amino-4-(2-phenylmethoxy-3,4-dimethoxy)phenyl-5-methyl-6-phenylmethoxy]-2-pyridinyl-6-methoxyquinoline-5,8-dione

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Technology Process of 2-[3-(N-phenylmethoxycarbonyl)amino-4-(2-phenylmethoxy-3,4-dimethoxy)phenyl-5-methyl-6-phenylmethoxy]-2-pyridinyl-6-methoxyquinoline-5,8-dione

There total 16 articles about 2-[3-(N-phenylmethoxycarbonyl)amino-4-(2-phenylmethoxy-3,4-dimethoxy)phenyl-5-methyl-6-phenylmethoxy]-2-pyridinyl-6-methoxyquinoline-5,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 957785-32-9
2-[5,6,8-trimethoxy-2-quinolinyl]-4-[3,4-dimethoxy-2-(phenylmethoxy)phenyl]-6-benzyloxy-5-methyl-3-(N-phenylmethoxycarbonyl)pyridinamine

: 957785-33-0
2-[3-(N-phenylmethoxycarbonyl)amino-4-(2-phenylmethoxy-3,4-dimethoxy)phenyl-5-methyl-6-phenylmethoxy]-2-pyridinyl-6-methoxyquinoline-5,8-dione

Guidance literature:: With ammonium cerium(IV) nitrate; In water; acetonitrile; at 0 ℃; for 0.75h;
DOI:10.1021/jo701435p

Reference yield:

: 957785-12-5
5,6,8-trimethoxy-(1H)-quinolin-4-one-2-carboxylic acid methyl ester

: 957785-33-0
2-[3-(N-phenylmethoxycarbonyl)amino-4-(2-phenylmethoxy-3,4-dimethoxy)phenyl-5-methyl-6-phenylmethoxy]-2-pyridinyl-6-methoxyquinoline-5,8-dione

Guidance literature:: Multi-step reaction with 11 steps

1.1: 88 percent / POCl₃ / benzene / 24 h / 20 °C

2.1: 100 percent / hydrogen; Et₃N / Pd-C / ethyl acetate / 0.75 h / 20 °C

3.1: NaH / toluene / 15 h / 110 °C

3.2: 78 percent / aq. HCl / dioxane / 15 h / 70 °C

4.1: 83 percent / NaOH / ethanol; H₂O / 15 h / 20 °C

5.1: 60 percent / potassium tert-butoxide / dimethylsulfoxide / 5 h / 100 °C

6.1: potassium carbonate; iodine monochloride / dimethylformamide / 16 h / 20 °C

7.1: 520 mg / Ag₂CO₃ / benzene / 72 h

8.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

8.2: 134 mg / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C

9.1: diphenylphosphoryl azide; Et₃N / benzene / 0.25 h / Heating

9.2: LiOH / tetrahydrofuran / 1 h / 20 °C

10.1: 85 mg / NaHCO₃ / tetrahydrofuran / 0 - 20 °C

11.1: 93 percent / cerium ammonium nitrate / acetonitrile; H₂O / 0.75 h / 0 °C

With sodium hydroxide; n-butyllithium; ammonium cerium(IV) nitrate; diphenylphosphoranyl azide; potassium tert-butylate; hydrogen; Iodine monochloride; sodium hydride; sodium hydrogencarbonate; potassium carbonate; triethylamine; silver carbonate; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; benzene;
DOI:10.1021/jo701435p

Reference yield:

: 957785-13-6
4-chloro-5,6,8-trimethoxyquinoline-2-carboxylic acid methyl ester

: 957785-33-0
2-[3-(N-phenylmethoxycarbonyl)amino-4-(2-phenylmethoxy-3,4-dimethoxy)phenyl-5-methyl-6-phenylmethoxy]-2-pyridinyl-6-methoxyquinoline-5,8-dione

Guidance literature:: Multi-step reaction with 10 steps

1.1: 100 percent / hydrogen; Et₃N / Pd-C / ethyl acetate / 0.75 h / 20 °C

2.1: NaH / toluene / 15 h / 110 °C

2.2: 78 percent / aq. HCl / dioxane / 15 h / 70 °C

3.1: 83 percent / NaOH / ethanol; H₂O / 15 h / 20 °C

4.1: 60 percent / potassium tert-butoxide / dimethylsulfoxide / 5 h / 100 °C

5.1: potassium carbonate; iodine monochloride / dimethylformamide / 16 h / 20 °C

6.1: 520 mg / Ag₂CO₃ / benzene / 72 h

7.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

7.2: 134 mg / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C

8.1: diphenylphosphoryl azide; Et₃N / benzene / 0.25 h / Heating

8.2: LiOH / tetrahydrofuran / 1 h / 20 °C

9.1: 85 mg / NaHCO₃ / tetrahydrofuran / 0 - 20 °C

10.1: 93 percent / cerium ammonium nitrate / acetonitrile; H₂O / 0.75 h / 0 °C

With sodium hydroxide; n-butyllithium; ammonium cerium(IV) nitrate; diphenylphosphoranyl azide; potassium tert-butylate; hydrogen; Iodine monochloride; sodium hydride; sodium hydrogencarbonate; potassium carbonate; triethylamine; silver carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; benzene;
DOI:10.1021/jo701435p