benzyl (5R,7S)-1-(3-fluorophenyl)-4-hydroxy-7-methyl-2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate

Base Information

Chemical Name:benzyl (5R,7S)-1-(3-fluorophenyl)-4-hydroxy-7-methyl-2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate
CAS No.:1227685-13-3
Molecular Formula:C₂₃H₂₅FN₂O₄
Molecular Weight:412.461
Hs Code.:

Synonyms:benzyl (5R,7S)-1-(3-fluorophenyl)-4-hydroxy-7-methyl-2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate

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Chemical Property of benzyl (5R,7S)-1-(3-fluorophenyl)-4-hydroxy-7-methyl-2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate

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Technology Process of benzyl (5R,7S)-1-(3-fluorophenyl)-4-hydroxy-7-methyl-2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate

There total 12 articles about benzyl (5R,7S)-1-(3-fluorophenyl)-4-hydroxy-7-methyl-2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1227685-11-1
benzyl (2S,4R)-4-cyano-4-[(3-ethoxy-3-oxopropanoyl)(3-fluorophenyl)amino]-2-methylpiperidine-1-carboxylate

: 1227685-13-3
benzyl (5R,7S)-1-(3-fluorophenyl)-4-hydroxy-7-methyl-2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate

Guidance literature:: With methanol; sodium tetrahydroborate; In tetrahydrofuran; at 0 ℃;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1227685-13-3
benzyl (5R,7S)-1-(3-fluorophenyl)-4-hydroxy-7-methyl-2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate

Guidance literature:: Multi-step reaction with 10 steps

1.1: triethylamine / tetrahydrofuran / 1 h / -50 - -10 °C

1.2: 3 h / -78 - 20 °C

2.1: acetic acid / zinc / 3 h / 60 °C

3.1: Chiralpak AD / methanol

4.1: lithium hexamethyldisilazane / tetrahydrofuran / -70 - -20 °C

4.2: 12 h / -5 - 5 °C

5.1: tetrabutyl ammonium fluoride; acetic acid / 2-methyltetrahydrofuran / 0.5 h / 20 °C

6.1: 0 °C

6.2: 12 h / -5 - 20 °C

7.1: -5 - 5 °C

7.2: -5 °C

8.1: sodium ethanolate / ethanol; 2-methyltetrahydrofuran / 4 h / 15 - 25 °C

9.1: water / 2-methyltetrahydrofuran / Reflux

10.1: sodium tetrahydroborate / 2-methyltetrahydrofuran / 15 - 25 °C

With sodium tetrahydroborate; tetrabutyl ammonium fluoride; water; sodium ethanolate; acetic acid; triethylamine; lithium hexamethyldisilazane; zinc; In tetrahydrofuran; 2-methyltetrahydrofuran; methanol; ethanol;

Reference yield:

: 190906-91-3
3,4-dihydro-2-methyl-4-oxo-1(2H)-pyridinecarboxylic acid phenylmethyl ester

: 1227685-13-3
benzyl (5R,7S)-1-(3-fluorophenyl)-4-hydroxy-7-methyl-2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: acetic acid / zinc / 3 h / 60 °C

2.1: Chiralpak AD / methanol

3.1: lithium hexamethyldisilazane / tetrahydrofuran / -70 - -20 °C

3.2: 12 h / -5 - 5 °C

4.1: tetrabutyl ammonium fluoride; acetic acid / 2-methyltetrahydrofuran / 0.5 h / 20 °C

5.1: 0 °C

5.2: 12 h / -5 - 20 °C

6.1: -5 - 5 °C

6.2: -5 °C

7.1: sodium ethanolate / ethanol; 2-methyltetrahydrofuran / 4 h / 15 - 25 °C

8.1: water / 2-methyltetrahydrofuran / Reflux

9.1: sodium tetrahydroborate / 2-methyltetrahydrofuran / 15 - 25 °C

With sodium tetrahydroborate; tetrabutyl ammonium fluoride; water; sodium ethanolate; acetic acid; lithium hexamethyldisilazane; zinc; In tetrahydrofuran; 2-methyltetrahydrofuran; methanol; ethanol;