N₁-(4'-cyanophenyl)-5-(2'',6''-dimethyl-4''-formylphenoxy)-4-methoxycarbonyl-2-nitroaniline

Base Information

• Chemical Name: N₁-(4'-cyanophenyl)-5-(2'',6''-dimethyl-4''-formylphenoxy)-4-methoxycarbonyl-2-nitroaniline
• CAS No.: 1372129-85-5
• Molecular Formula: C₂₄H₁₉N₃O₆
• Molecular Weight: 445.431

Synonyms:N₁-(4'-cyanophenyl)-5-(2'',6''-dimethyl-4''-formylphenoxy)-4-methoxycarbonyl-2-nitroaniline

Chemical Property of N₁-(4'-cyanophenyl)-5-(2'',6''-dimethyl-4''-formylphenoxy)-4-methoxycarbonyl-2-nitroaniline

Chemical Property:

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Technology Process of N₁-(4'-cyanophenyl)-5-(2'',6''-dimethyl-4''-formylphenoxy)-4-methoxycarbonyl-2-nitroaniline

There total 5 articles about N₁-(4'-cyanophenyl)-5-(2'',6''-dimethyl-4''-formylphenoxy)-4-methoxycarbonyl-2-nitroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

4-hydroxy-3,5-dimethylbenzaldehyde (2233-18-3) + 5-chloro-N1-(4-cyanophenyl)-4-methoxycarbonyl-2-nitroaniline (1372129-84-4) → N1-(4'-cyanophenyl)-5-(2'',6''-dimethyl-4''-formylphenoxy)-4-methoxycarbonyl-2-nitroaniline (1372129-85-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 190 ℃; for 0.25h; Microwave irradiation;

DOI:10.1016/j.bmcl.2012.02.055

Reference yield:

2,4 dichlorobenzoic acid (50-84-0) → N1-(4'-cyanophenyl)-5-(2'',6''-dimethyl-4''-formylphenoxy)-4-methoxycarbonyl-2-nitroaniline (1372129-85-5)

Guidance literature:

Multi-step reaction with 4 steps

1: sulfuric acid; nitric acid / 2 h / 0 - 20 °C

2: sulfuric acid / 2 h / Reflux

3: caesium carbonate / N,N-dimethyl-formamide / 10 h / 100 °C

4: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 190 °C / Microwave irradiation

With sulfuric acid; nitric acid; potassium carbonate; caesium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.02.055

Reference yield:

methyl 2,4-dichloro-5-nitrobenzoate (101495-62-9) → N1-(4'-cyanophenyl)-5-(2'',6''-dimethyl-4''-formylphenoxy)-4-methoxycarbonyl-2-nitroaniline (1372129-85-5)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 10 h / 100 °C

2: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 190 °C / Microwave irradiation

With potassium carbonate; caesium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.02.055

upstream raw materials:

4-hydroxy-3,5-dimethylbenzaldehyde

5-chloro-N¹-(4-cyanophenyl)-4-methoxycarbonyl-2-nitroaniline

2,4 dichlorobenzoic acid

methyl 2,4-dichloro-5-nitrobenzoate

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