2,4-Dichloro-5-nitro-benzoic acid Methyl ester

Base Information

• Chemical Name: 2,4-Dichloro-5-nitro-benzoic acid Methyl ester
• CAS No.: 101495-62-9
• Molecular Formula: C8H5Cl2NO4
• Molecular Weight: 250.038
• Mol file: 101495-62-9.mol

Synonyms:2,4-Dichloro-5-nitro-benzoic acid Methyl ester

Chemical Property of 2,4-Dichloro-5-nitro-benzoic acid Methyl ester

Chemical Property:

• PSA: 72.12000
• LogP: 3.21140

Purity/Quality:

99% ^*data from raw suppliers

Methyl 2,4-dichloro-5-nitrobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Dichloro-5-nitro-benzoic acid Methyl ester

There total 3 articles about 2,4-Dichloro-5-nitro-benzoic acid Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl 2,4-dichlorobenzoate (35112-28-8) → methyl 2,4-dichloro-5-nitrobenzoate (101495-62-9)

Guidance literature:

With sulfuric acid; nitric acid; at 0 - 20 ℃; for 18h;

Reference yield: 86.0%

methanol (67-56-1) + 2,4-dichloro-5-nitrobenzoic acid (19861-62-2) → methyl 2,4-dichloro-5-nitrobenzoate (101495-62-9)

Guidance literature:

With sulfuric acid; for 2h; Reflux;

DOI:10.1021/jm3007678

Reference yield:

2,4 dichlorobenzoic acid (50-84-0) → methyl 2,4-dichloro-5-nitrobenzoate (101495-62-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; nitric acid / 2 h / 0 - 20 °C

2: sulfuric acid / 2 h / Reflux

With sulfuric acid; nitric acid;

DOI:10.1016/j.bmcl.2012.02.055

upstream raw materials:

methanol

2,4-dichloro-5-nitrobenzoic acid

2,4 dichlorobenzoic acid

methyl 2,4-dichlorobenzoate

Downstream raw materials:

methyl 5-amino-2,4-dichlorobenzoate

N₁-(4'-cyanophenyl)-5-(2'',6''-dimethyl-4''-formylphenoxy)-4-methoxycarbonyl-2-nitroaniline

5-chloro-N¹-(4-cyanophenyl)-4-methoxycarbonyl-2-nitroaniline

C₂₆H₂₂N₄O₃