3'-(4-acetoxybutyl)-3,5-dinitro-O-methyl-N-(trifluoroacetyl)-L-thyronine ethyl ester

Base Information

Chemical Name:3'-(4-acetoxybutyl)-3,5-dinitro-O-methyl-N-(trifluoroacetyl)-L-thyronine ethyl ester
CAS No.:111088-10-9
Molecular Formula:C₂₆H₂₈F₃N₃O₁₁
Molecular Weight:615.517
Hs Code.:

Synonyms:3'-(4-acetoxybutyl)-3,5-dinitro-O-methyl-N-(trifluoroacetyl)-L-thyronine ethyl ester

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Chemical Property of 3'-(4-acetoxybutyl)-3,5-dinitro-O-methyl-N-(trifluoroacetyl)-L-thyronine ethyl ester

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Technology Process of 3'-(4-acetoxybutyl)-3,5-dinitro-O-methyl-N-(trifluoroacetyl)-L-thyronine ethyl ester

There total 5 articles about 3'-(4-acetoxybutyl)-3,5-dinitro-O-methyl-N-(trifluoroacetyl)-L-thyronine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52329-06-3
5-(benzyloxy)-2-methoxybenzaldehyde

: 111088-10-9
3'-(4-acetoxybutyl)-3,5-dinitro-O-methyl-N-(trifluoroacetyl)-L-thyronine ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 56 percent / dicyclohexylamino-18-crown-6, KOBu-t / CH₂Cl₂ / Ambient temperature

2: 63 percent / H₂ / Pd/C / ethanol / 10 °C / 2068.6 Torr

3: 1.) CH₃SO₂Cl / 1.) pyridine, reflux, 10 min, 2.) reflux, 1 h

With perhydrodibenzo-18-crown-6; potassium tert-butylate; hydrogen; methanesulfonyl chloride; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm00396a008

Reference yield:

: 35431-26-6
5-hydroxy-2-methoxybenzaldehyde

: 111088-10-9
3'-(4-acetoxybutyl)-3,5-dinitro-O-methyl-N-(trifluoroacetyl)-L-thyronine ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / adogen 464, NaOH / CH₂Cl₂; H₂O / 2 h

2: 56 percent / dicyclohexylamino-18-crown-6, KOBu-t / CH₂Cl₂ / Ambient temperature

3: 63 percent / H₂ / Pd/C / ethanol / 10 °C / 2068.6 Torr

4: 1.) CH₃SO₂Cl / 1.) pyridine, reflux, 10 min, 2.) reflux, 1 h

With perhydrodibenzo-18-crown-6; sodium hydroxide; adogen 464; potassium tert-butylate; hydrogen; methanesulfonyl chloride; palladium on activated charcoal; In ethanol; dichloromethane; water;
DOI:10.1021/jm00396a008

Reference yield:

: 30698-17-0
(3-acetoxypropyl)triphenylphosphonium bromide

: 111088-10-9
3'-(4-acetoxybutyl)-3,5-dinitro-O-methyl-N-(trifluoroacetyl)-L-thyronine ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 56 percent / dicyclohexylamino-18-crown-6, KOBu-t / CH₂Cl₂ / Ambient temperature

2: 63 percent / H₂ / Pd/C / ethanol / 10 °C / 2068.6 Torr

3: 1.) CH₃SO₂Cl / 1.) pyridine, reflux, 10 min, 2.) reflux, 1 h

With perhydrodibenzo-18-crown-6; potassium tert-butylate; hydrogen; methanesulfonyl chloride; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm00396a008