8-bromo-3-[(4-methylphenyl)sulfonyl]-5-{[3,4,5-tris(methyloxy)phenyl]amino}pyrrolo[2',3':4,5]pyrimido[6,1-b]quinazolin-7(3H)-one hydrochloride

Base Information

• Chemical Name: 8-bromo-3-[(4-methylphenyl)sulfonyl]-5-{[3,4,5-tris(methyloxy)phenyl]amino}pyrrolo[2',3':4,5]pyrimido[6,1-b]quinazolin-7(3H)-one hydrochloride
• CAS No.: 1135823-24-3
• Molecular Formula: C₂₉H₂₄BrN₅O₆S
• Molecular Weight: 650.509

Synonyms:8-bromo-3-[(4-methylphenyl)sulfonyl]-5-{[3,4,5-tris(methyloxy)phenyl]amino}pyrrolo[2',3':4,5]pyrimido[6,1-b]quinazolin-7(3H)-one hydrochloride

Chemical Property of 8-bromo-3-[(4-methylphenyl)sulfonyl]-5-{[3,4,5-tris(methyloxy)phenyl]amino}pyrrolo[2',3':4,5]pyrimido[6,1-b]quinazolin-7(3H)-one hydrochloride

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Technology Process of 8-bromo-3-[(4-methylphenyl)sulfonyl]-5-{[3,4,5-tris(methyloxy)phenyl]amino}pyrrolo[2',3':4,5]pyrimido[6,1-b]quinazolin-7(3H)-one hydrochloride

There total 1 articles about 8-bromo-3-[(4-methylphenyl)sulfonyl]-5-{[3,4,5-tris(methyloxy)phenyl]amino}pyrrolo[2',3':4,5]pyrimido[6,1-b]quinazolin-7(3H)-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

8-bromo-5-chloro-3-[(4-methylphenyl)sulfonyl]pyrrolo[2',3':4,5]pyrimido[6,1-b]quinazolin-7(3H)-one hydrochloride (1116238-40-4) + 3,4,5-Trimethoxyaniline (24313-88-0) → 8-bromo-3-[(4-methylphenyl)sulfonyl]-5-{[3,4,5-tris(methyloxy)phenyl]amino}pyrrolo[2',3':4,5]pyrimido[6,1-b]quinazolin-7(3H)-one hydrochloride (1135823-24-3)

Guidance literature:

In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jo8020693

Reference yield: 71.0%

methanol (67-56-1) + 8-bromo-3-[(4-methylphenyl)sulfonyl]-5-{[3,4,5-tris(methyloxy)phenyl]amino}pyrrolo[2',3':4,5]pyrimido[6,1-b]quinazolin-7(3H)-one hydrochloride (1135823-24-3) → methyl 2-bromo-6-[(7-[(4-methylphenyl)sulfonyl]-2-{[3,4,5-tris(methoxy)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]benzoate (1086611-12-2)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jo8020693

upstream raw materials:

8-bromo-5-chloro-3-[(4-methylphenyl)sulfonyl]pyrrolo[2',3':4,5]pyrimido[6,1-b]quinazolin-7(3H)-one hydrochloride

3,4,5-Trimethoxyaniline

Downstream raw materials:

methyl 2-bromo-6-[(7-[(4-methylphenyl)sulfonyl]-2-{[3,4,5-tris(methoxy)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]benzoate

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