tert-butyl 4-(2,3-dimethoxyphenyl)-4-<4-(1-methyl-3-methylene-2-oxopiperidinyl)>-3-oxobutyrate

Base Information

Chemical Name:tert-butyl 4-(2,3-dimethoxyphenyl)-4-<4-(1-methyl-3-methylene-2-oxopiperidinyl)>-3-oxobutyrate
CAS No.:81012-11-5
Molecular Formula:C₂₃H₃₁NO₆
Molecular Weight:417.502
Hs Code.:

Synonyms:tert-butyl 4-(2,3-dimethoxyphenyl)-4-<4-(1-methyl-3-methylene-2-oxopiperidinyl)>-3-oxobutyrate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 4-(2,3-dimethoxyphenyl)-4-<4-(1-methyl-3-methylene-2-oxopiperidinyl)>-3-oxobutyrate

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Technology Process of tert-butyl 4-(2,3-dimethoxyphenyl)-4-<4-(1-methyl-3-methylene-2-oxopiperidinyl)>-3-oxobutyrate

There total 2 articles about tert-butyl 4-(2,3-dimethoxyphenyl)-4-<4-(1-methyl-3-methylene-2-oxopiperidinyl)>-3-oxobutyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79619-11-7
4-(Carboxymethyl)-4-(2,3-dimethoxyphenyl)-1-methyl-3-methylene-2-piperidinone

: 81012-11-5
tert-butyl 4-(2,3-dimethoxyphenyl)-4-<4-(1-methyl-3-methylene-2-oxopiperidinyl)>-3-oxobutyrate

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / CH₂Cl₂ / 9.5 h / Ambient temperature

2: 1.) isopropylmagnesium bromide / 1.) THF, RT, 4 h, and reflux, 45 min, 2.) THF, RT, 3 d

With isopropylmagnesium bromide; In dichloromethane;
DOI:10.1021/jo00349a006

Reference yield:

: 81012-10-4
imidazolide of 4-(carboxymethyl)-4-(2,3-dimethoxyphenyl)-1-methyl-3-methylene-2-piperidinone

: 73859-00-4
lithium tert-butyl malonate

: 81012-11-5
tert-butyl 4-(2,3-dimethoxyphenyl)-4-<4-(1-methyl-3-methylene-2-oxopiperidinyl)>-3-oxobutyrate

Guidance literature:: With isopropylmagnesium bromide; Yield given. Multistep reaction; 1.) THF, RT, 4 h, and reflux, 45 min, 2.) THF, RT, 3 d;
DOI:10.1021/jo00349a006