3(R)-methyl-6(S)-<1(R)-methyl-2-(phenylmethoxy)ethyl>-2(S)-(3-oxobutyl)cyclohexanone

Base Information

Chemical Name:3(R)-methyl-6(S)-<1(R)-methyl-2-(phenylmethoxy)ethyl>-2(S)-(3-oxobutyl)cyclohexanone
CAS No.:93913-62-3
Molecular Formula:C₂₁H₃₀O₃
Molecular Weight:330.467
Hs Code.:

Synonyms:3(R)-methyl-6(S)-<1(R)-methyl-2-(phenylmethoxy)ethyl>-2(S)-(3-oxobutyl)cyclohexanone

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Chemical Property of 3(R)-methyl-6(S)-<1(R)-methyl-2-(phenylmethoxy)ethyl>-2(S)-(3-oxobutyl)cyclohexanone

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Technology Process of 3(R)-methyl-6(S)-<1(R)-methyl-2-(phenylmethoxy)ethyl>-2(S)-(3-oxobutyl)cyclohexanone

There total 12 articles about 3(R)-methyl-6(S)-<1(R)-methyl-2-(phenylmethoxy)ethyl>-2(S)-(3-oxobutyl)cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 84051-33-2
(2S,3R,6S)-6-((R)-1-(benzyloxy)prop-2-yl)-3-methyl-2-((E)-3-(trimethylsilyl)but-2-en-1-yl)cyclohexanone

: 93913-62-3
3(R)-methyl-6(S)-<1(R)-methyl-2-(phenylmethoxy)ethyl>-2(S)-(3-oxobutyl)cyclohexanone

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 8h; Inert atmosphere;
DOI:10.1016/j.tet.2016.06.066

Reference yield: 41.0%

: 43209-86-5
3-trimethylsilyl-3-buten-2-one

: 84051-32-1
(2S,5R)-2-((R)-1-(benzyloxy)propan-2-yl)-5-methylcyclohexanone

: 93913-62-3
3(R)-methyl-6(S)-<1(R)-methyl-2-(phenylmethoxy)ethyl>-2(S)-(3-oxobutyl)cyclohexanone

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; hexane; -78 deg C, 1 h, 0 deg C, 2.5 h;
DOI:10.1080/00397919608003621

Reference yield:

: 13834-07-6
(1R,3R,4S,8R)-9-hydroxy-p-menthol

: 93913-62-3
3(R)-methyl-6(S)-<1(R)-methyl-2-(phenylmethoxy)ethyl>-2(S)-(3-oxobutyl)cyclohexanone

Guidance literature:: Multi-step reaction with 3 steps

1: 59 percent / NaH / dimethylformamide / 3 h / 10 - 15 °C

2: 91 percent / pyridinium dichromate / dimethylformamide / 24 h / Ambient temperature

3: 41 percent / lithium diisopropylamide / tetrahydrofuran; hexane / -78 deg C, 1 h, 0 deg C, 2.5 h

With dipyridinium dichromate; sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1080/00397919608003621