(R)-2-[(1S,3S,4R)-2-[1-Methoxy-meth-(Z)-ylidene]-4-methyl-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester

Base Information

Chemical Name:(R)-2-[(1S,3S,4R)-2-[1-Methoxy-meth-(Z)-ylidene]-4-methyl-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester
CAS No.:87322-20-1
Molecular Formula:C₁₇H₂₈O₄
Molecular Weight:296.407
Hs Code.:

Synonyms:(R)-2-[(1S,3S,4R)-2-[1-Methoxy-meth-(Z)-ylidene]-4-methyl-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester

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Chemical Property of (R)-2-[(1S,3S,4R)-2-[1-Methoxy-meth-(Z)-ylidene]-4-methyl-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester

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Technology Process of (R)-2-[(1S,3S,4R)-2-[1-Methoxy-meth-(Z)-ylidene]-4-methyl-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester

There total 21 articles about (R)-2-[(1S,3S,4R)-2-[1-Methoxy-meth-(Z)-ylidene]-4-methyl-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.5%

: 87322-21-2
(R)-2-{(1S,3S,4R)-2-[1-Methoxy-meth-(Z)-ylidene]-4-methyl-3-[2-(2-methyl-[1,3]dithian-2-yl)-ethyl]-cyclohexyl}-propionic acid methyl ester

: 87322-20-1
(R)-2-[(1S,3S,4R)-2-[1-Methoxy-meth-(Z)-ylidene]-4-methyl-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester

Guidance literature:: With calcium carbonate; mercury dichloride; In water; acetonitrile; for 3h; Heating;
DOI:10.1016/S0040-4020(01)87487-1

Reference yield: 80.0%

: 503272-16-0
(R)-2-{(1S,3S,4R)-2-[1-Methoxy-meth-(E)-ylidene]-4-methyl-3-[2-(2-methyl-[1,3]dithiolan-2-yl)-ethyl]-cyclohexyl}-propionic acid methyl ester

: 87322-20-1
(R)-2-[(1S,3S,4R)-2-[1-Methoxy-meth-(Z)-ylidene]-4-methyl-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester

Guidance literature:: With calcium carbonate; mercury dichloride; In water; acetonitrile;
DOI:10.1016/S0040-4039(02)02500-5

Reference yield:

: 5113-87-1
3-methyl-6-(prop-1-en-2-yl)cyclohexene

: 87322-20-1
(R)-2-[(1S,3S,4R)-2-[1-Methoxy-meth-(Z)-ylidene]-4-methyl-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: dicyclohexylborane / tetrahydrofuran / 168 h / 0 °C

1.2: 82 percent / H₂O₂; OH^(1-)

2.1: 80 percent / CrO₃; H₂SO₄ / acetone / 0 °C

3.1: KI; NaHCO₃ (aq.) / 48 h

4.1: 72 percent / (Me₃Si)3SiH; AIBN / toluene

5.1: BF₃*Et₂O / CH₂Cl₂ / 0 °C

6.1: NaOH (10 percent in MeOH) / Heating

7.1: diethyl ether

8.1: 89 percent / PCC / CH₂Cl₂ / 0 °C

9.1: 45 percent / KHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / 24 h / 50 °C

10.1: 80 percent / HgCl₂; CaCO₃ / acetonitrile; H₂O

With chromium(VI) oxide; sodium hydroxide; 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; sulfuric acid; boron trifluoride diethyl etherate; bis(cyclohexanyl)borane; potassium hexamethylsilazane; sodium hydrogencarbonate; pyridinium chlorochromate; calcium carbonate; potassium iodide; mercury dichloride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; water; acetone; toluene; acetonitrile; 2.1: Jones oxidation;
DOI:10.1016/S0040-4039(02)02500-5