(2,4-Difluoro-phenyl)-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone

Base Information

Chemical Name:(2,4-Difluoro-phenyl)-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone
CAS No.:220603-13-4
Molecular Formula:C₁₉H₁₃F₂N₃O
Molecular Weight:337.329
Hs Code.:

Synonyms:(2,4-Difluoro-phenyl)-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone

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Chemical Property of (2,4-Difluoro-phenyl)-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone

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Technology Process of (2,4-Difluoro-phenyl)-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone

There total 9 articles about (2,4-Difluoro-phenyl)-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 72482-64-5
2,4-difluorobenzoyl chloride

: 16287-36-8
6,11-dihydro-5H-pyrido{2,3-b][1,5]benzodiazepine

: 220603-13-4
(2,4-Difluoro-phenyl)-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone

Guidance literature:: With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.333333h;

Reference yield:

: 1583-58-0
2,4-difluoro-benzoic acid

: 220603-13-4
(2,4-Difluoro-phenyl)-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride / dimethylformamide; CH₂Cl₂ / Heating

2: K₂CO₃ / dimethylformamide

With oxalyl dichloride; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.10.107

Reference yield:

: 6,11-dihydro-5H-benzo[b]pyrido[2,3-e][1,4]diazepin-5-one hydrochloride

: 220603-13-4
(2,4-Difluoro-phenyl)-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / BH₃*SMe₂ / dioxane / 20 °C / sonication

2: K₂CO₃ / dimethylformamide

With dimethylsulfide borane complex; potassium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.10.107