[2-fluoro-4-(3-methyl-1H-pyrazol-1-yl)-phenyl]-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone

Base Information

• Chemical Name: [2-fluoro-4-(3-methyl-1H-pyrazol-1-yl)-phenyl]-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone
• CAS No.: 220602-72-2
• Molecular Formula: C₂₃H₁₈FN₅O
• Molecular Weight: 399.427

Synonyms:[2-fluoro-4-(3-methyl-1H-pyrazol-1-yl)-phenyl]-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone

Chemical Property of [2-fluoro-4-(3-methyl-1H-pyrazol-1-yl)-phenyl]-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone

Chemical Property:

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Technology Process of [2-fluoro-4-(3-methyl-1H-pyrazol-1-yl)-phenyl]-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone

There total 13 articles about [2-fluoro-4-(3-methyl-1H-pyrazol-1-yl)-phenyl]-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.7%

(2,4-Difluoro-phenyl)-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone (220603-13-4) + 3-Methylpyrazole (1453-58-3) → [2-fluoro-4-(3-methyl-1H-pyrazol-1-yl)-phenyl]-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone (220602-72-2) + [4-fluoro-2-(3-methyl-1H-pyrazol-1-yl)-phenyl]-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone

Guidance literature:

With sodium hydride; In DMF (N,N-dimethyl-formamide); at 130 ℃;

Reference yield:

(2,4-Difluoro-phenyl)-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone (220603-13-4) + 3-Methylpyrazole (1453-58-3) + (2,4-difluoro-phenyl)-(6,11-dihydro-1H-pyrido[2,3-b][1,5]benzodiazepin-10-yl)-methanone → [2-fluoro-4-(3-methyl-1H-pyrazol-1-yl)-phenyl]-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone (220602-72-2)

Guidance literature:

In N-methyl-acetamide; dichloromethane;

Reference yield:

(2,4-Difluoro-phenyl)-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone (220603-13-4) + 3-Methylpyrazole (1453-58-3) → [2-fluoro-4-(3-methyl-1H-pyrazol-1-yl)-phenyl]-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone (220602-72-2) + (5,11-dihydro-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)-[2-fluoro-4-(5-methyl-pyrazol-1-yl)-phenyl]-methanone + [4-fluoro-2-(3-methyl-1H-pyrazol-1-yl)-phenyl]-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 130 ℃;

DOI:10.1016/j.bmcl.2005.10.107

upstream raw materials:

(2,4-Difluoro-phenyl)-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone

3-Methylpyrazole

2-chloronicotinic acid

2,4-difluorobenzoyl chloride

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