(2S,3S)-8-Chloro-5-(2-dimethylamino-ethyl)-3-hydroxy-2-p-tolyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

Base Information

Chemical Name:(2S,3S)-8-Chloro-5-(2-dimethylamino-ethyl)-3-hydroxy-2-p-tolyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one
CAS No.:122666-80-2
Molecular Formula:C₂₀H₂₃ClN₂O₂S
Molecular Weight:390.934
Hs Code.:

Synonyms:(2S,3S)-8-Chloro-5-(2-dimethylamino-ethyl)-3-hydroxy-2-p-tolyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S)-8-Chloro-5-(2-dimethylamino-ethyl)-3-hydroxy-2-p-tolyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

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Technology Process of (2S,3S)-8-Chloro-5-(2-dimethylamino-ethyl)-3-hydroxy-2-p-tolyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

There total 13 articles about (2S,3S)-8-Chloro-5-(2-dimethylamino-ethyl)-3-hydroxy-2-p-tolyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 4584-46-7
(2-chloroethyl)dimethylamine hydrochloride

: 122666-79-9
(2S,3S)-8-Chloro-3-hydroxy-2-p-tolyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

: 122666-80-2
(2S,3S)-8-Chloro-5-(2-dimethylamino-ethyl)-3-hydroxy-2-p-tolyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

Guidance literature:: With potassium carbonate; In acetone; for 17h; Heating;
DOI:10.1021/jm00106a032

Reference yield: 81.0%

: 145476-02-4
8-Chloro-5-(2-dimethylamino-ethyl)-2-p-tolyl-5H-benzo[b][1,4]thiazepine-3,4-dione

: 122666-80-2
(2S,3S)-8-Chloro-5-(2-dimethylamino-ethyl)-3-hydroxy-2-p-tolyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 0 - 25 ℃; for 0.5h;
DOI:10.1248/cpb.40.1986

Reference yield:

: 23474-98-8
2-amino-5-chlorobenzenethiol

: 122666-80-2
(2S,3S)-8-Chloro-5-(2-dimethylamino-ethyl)-3-hydroxy-2-p-tolyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: 45 percent / toluene / 24 h / 130 °C

2: 90.5 percent / 5percent aq. NaOH / ethanol / 3 h / Ambient temperature

3: 84 percent / xylene / 24 h / Heating

4: 84 percent / aq. K₂CO₃ / acetone / 17 h / Heating

With sodium hydroxide; potassium carbonate; In ethanol; acetone; toluene; xylene;
DOI:10.1021/jm00106a032